Literature DB >> 228305

Endogenous digitalis-like activity in mammalian brain.

M C Fishman.   

Abstract

A fraction of brain has been prepared that contains a substance mimicking actions of the digitalis glycosides. It both blocks the binding of [3H]ouabain to Na+,K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) and inhibits the uptake of 86Rb+ into human erythrocytes. Partial isolation was achieved by Sephadex G-10 fractionation and subsequent desalting. This activity is potentially capable of regulating ionic fluxes and concentration gradients across the cell membrane.

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Year:  1979        PMID： 228305      PMCID： PMC411640          DOI： 10.1073/pnas.76.9.4661

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  The influence of some cations on an adenosine triphosphatase from peripheral nerves.

Authors:  J C SKOU
Journal:  Biochim Biophys Acta       Date:  1957-02

2.  Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport.

Authors:  J S Flier
Journal:  Nature       Date:  1978-07-20       Impact factor: 49.962

Review 3.  Regulation of cellular volume.

Authors:  A D Macknight; A Leaf
Journal:  Physiol Rev       Date:  1977-07       Impact factor: 37.312

4.  Sodium transport inhibitor from bovine hypothalamus.

Authors:  G T Haupert; J M Sancho
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

5.  Studies on cardiotonic steroids from the skin of Japanese toad.

Authors:  K Shimada; Y Fujii; E Yamashita; Y Niizaki; Y Sato
Journal:  Chem Pharm Bull (Tokyo)       Date:  1977-04       Impact factor: 1.645

6.  Cardiac glycosides in the defensive secretion of chrysomelid beetles: evidence for their production by the insects.

Authors:  J M Pasteels; D Daloze
Journal:  Science       Date:  1977-07-01       Impact factor: 47.728

Review 7.  Digitalis. I.

Authors:  T W Smith; E Haber
Journal:  N Engl J Med       Date:  1973-11-01       Impact factor: 91.245

Review 8.  The sodium-potassium adenosinetriphosphatase.

Authors:  J L Dahl; L E Hokin
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

9.  Serum cardiac glycoside assay based upon displacement of 3 H-ouabain from Na-K ATPase.

Authors:  G Brooker; R W Jelliffe
Journal:  Circulation       Date:  1972-01       Impact factor: 29.690

10.  Cardioactive substances in the monarch butterfly and Euploea core reared on leaf-free artificial diet.

Authors:  M Rothschild; N Marsh; B Gardiner
Journal:  Nature       Date:  1978-10-19       Impact factor: 49.962
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  27 in total

Review 1.  How many endobains are there?

Authors:  G Rodríguez de Lores Arnaiz
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

Review 2.  Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function.

Authors:  D Lichtstein; H Rosen
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

Review 3.  Endogenous factors with immunological and biological activity similar to cardiac glycosides: biochemical and pathophysiological implications.

Authors:  A Clerico; G Mariani
Journal:  J Endocrinol Invest       Date:  1992-05       Impact factor: 4.256

Review 4.  In search of synaptosomal Na+,K(+)-ATPase regulators.

Authors:  G Rodríguez de Lores Arnaiz
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

5.  Sodium transport inhibitor from bovine hypothalamus.

Authors:  G T Haupert; J M Sancho
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

6.  Arrestins and spinophilin competitively regulate Na+,K+-ATPase trafficking through association with a large cytoplasmic loop of the Na+,K+-ATPase.

Authors:  Tohru Kimura; Patrick B Allen; Angus C Nairn; Michael J Caplan
Journal:  Mol Biol Cell       Date:  2007-09-05       Impact factor: 4.138

7.  Effect of tissue specificity of brain soluble fractions on Na+, K(+)-ATPase activity.

Authors:  G Rodríguez de Lores Arnaiz
Journal:  Neurochem Res       Date:  1990-03       Impact factor: 3.996

Review 8.  The endogenous digitalis-like factor.

Authors:  F Kölbel; V Schreiber
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

Review 9.  Role of the Astrocytic Na(+), K(+)-ATPase in K(+) Homeostasis in Brain: K(+) Uptake, Signaling Pathways and Substrate Utilization.

Authors:  Leif Hertz; Dan Song; Junnan Xu; Liang Peng; Marie E Gibbs
Journal:  Neurochem Res       Date:  2015-01-03       Impact factor: 3.996

10.  Partial characterization of an endogenous factor which modulates the effect of catecholamines on synaptosomal Na+, K+-ATPase.

Authors:  G Rodríguez de Lores Arnaiz; M Antonelli de Gómez de Lima
Journal:  Neurochem Res       Date:  1986-07       Impact factor: 3.996
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