Literature DB >> 228304

Sodium transport inhibitor from bovine hypothalamus.

G T Haupert, J M Sancho.   

Abstract

A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+,K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.

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Year:  1979        PMID： 228304      PMCID： PMC411639          DOI： 10.1073/pnas.76.9.4658

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog.

Authors:  H E DE WARDENER; I H MILLS; W F CLAPHAM; C J HAYTER
Journal:  Clin Sci       Date:  1961-10       Impact factor: 6.124

2.  Water and sodium excretion after blood volume expansion under conditions of constant arterial, venous and plasma oncotic pressures and constant haematocrit.

Authors:  B Lichardus; A Nizet
Journal:  Clin Sci       Date:  1972-06       Impact factor: 6.124

3.  The role of Na-K-activated adenosine triphosphatase in potassium adaptation. Stimulation of enzymatic activity by potassium loading.

Authors:  P Silva; J P Hayslett; F H Epstein
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

4.  Saluretic activity of blood during carotid occlusion in the cat.

Authors:  J H Cort; T Dousa; V Pliska; B Lichardus; J Safárová; M Vranesić; J Rudinger
Journal:  Am J Physiol       Date:  1968-10

5.  The effect of dialysates and ultrafiltrates of plasma of saline-loaded dogs on toad bladder sodium transport.

Authors:  V M Buckalew; F J Martinez; W E Green
Journal:  J Clin Invest       Date:  1970-05       Impact factor: 14.808

6.  Endogenous digitalis-like activity in mammalian brain.

Authors:  M C Fishman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

7.  Modulation of ouabain binding and potassium pump fluxes by cellular sodium and potassium in human and sheep erythrocytes.

Authors:  C H Joiner; P K Lauf
Journal:  J Physiol       Date:  1978-10       Impact factor: 5.182

8.  Evidence that the brain participates in the humoral natriuretic mechanism of blood volume expansion in the dog.

Authors:  G J Kaloyanides; M B Balabanian; R L Bowman
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

9.  Inhibition of transepithelial sodium transport in the frog skin by a low molecular weight fraction of uremic serum.

Authors:  J Bourgoignie; S Klahr; N S Bricker
Journal:  J Clin Invest       Date:  1971-02       Impact factor: 14.808

10.  Active sodium transport by the isolated toad bladder.

Authors:  A LEAF; J ANDERSON; L B PAGE
Journal:  J Gen Physiol       Date:  1958-03-20       Impact factor: 4.086
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  33 in total

Review 1.  Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function.

Authors:  D Lichtstein; H Rosen
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

Review 2.  Endogenous factors with immunological and biological activity similar to cardiac glycosides: biochemical and pathophysiological implications.

Authors:  A Clerico; G Mariani
Journal:  J Endocrinol Invest       Date:  1992-05       Impact factor: 4.256

Review 3.  In search of synaptosomal Na+,K(+)-ATPase regulators.

Authors:  G Rodríguez de Lores Arnaiz
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

4.  Arrestins and spinophilin competitively regulate Na+,K+-ATPase trafficking through association with a large cytoplasmic loop of the Na+,K+-ATPase.

Authors:  Tohru Kimura; Patrick B Allen; Angus C Nairn; Michael J Caplan
Journal:  Mol Biol Cell       Date:  2007-09-05       Impact factor: 4.138

Review 5.  Digitalislike circulating factor in hypertension: potential messenger between salt balance and intracellular sodium.

Authors:  F J Haddy
Journal:  Cardiovasc Drugs Ther       Date:  1990-03       Impact factor: 3.727

Review 6.  [Endogenous natriuretic and ouabain-like factors. Their potential role in volume and blood pressure regulation].

Authors:  H J Kramer; A Bäcker; G Krampitz; H Meyer-Lehnert; H Michel
Journal:  Klin Wochenschr       Date:  1990-11-16

7.  Effect of tissue specificity of brain soluble fractions on Na+, K(+)-ATPase activity.

Authors:  G Rodríguez de Lores Arnaiz
Journal:  Neurochem Res       Date:  1990-03       Impact factor: 3.996

Review 8.  The endogenous digitalis-like factor.

Authors:  F Kölbel; V Schreiber
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

9.  Positive inotropic effects of the endogenous Na+/K(+)-transporting ATPase inhibitor from the hypothalamus.

Authors:  H A Hallaq; G T Haupert
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

10.  Circulating endogenous digitalis-like factor(s) (EDLF) in man is derived from the adrenals and its secretion is ACTH-dependent.

Authors:  A Sophocleous; I Elmatzoglou; A Souvatzoglou
Journal:  J Endocrinol Invest       Date:  2003-07       Impact factor: 4.256
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