Literature DB >> 22829421

An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo.

Tianzhu Yu1, Xiaoxuan Liu, Anne-Laure Bolcato-Bellemin, Yang Wang, Cheng Liu, Patrick Erbacher, Fanqi Qu, Palma Rocchi, Jean-Paul Behr, Ling Peng.   

Abstract

An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein 27 siRNA and produce potent gene silencing and anticancer activity in vitro and in vivo in a prostate cancer model. This dendrimer can be used alternatively for treating various diseases.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22829421     DOI： 10.1002/anie.201203920

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  36 in total

1.  Nanomaterials as Non-viral siRNA Delivery Agents for Cancer Therapy.

Authors:  Sanjay Singh
Journal:  Bioimpacts       Date:  2013-01-14

2.  ITC for Characterization of Self-Assembly Process of Cationic Dendrons for siRNA Delivery.

Authors:  Erik Laurini; Suzana Aulic; Natasa Skoko; Domenico Marson; Maurizio Fermeglia; Sabrina Pricl
Journal:  Methods Mol Biol       Date:  2021

3.  Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing.

Authors:  Chao Chen; Paola Posocco; Xiaoxuan Liu; Qiang Cheng; Erik Laurini; Jiehua Zhou; Cheng Liu; Yang Wang; Jingjie Tang; Valentina Dal Col; Tianzhu Yu; Suzanne Giorgio; Maurizio Fermeglia; Fanqi Qu; Zicai Liang; John J Rossi; Minghua Liu; Palma Rocchi; Sabrina Pricl; Ling Peng
Journal:  Small       Date:  2016-05-31       Impact factor: 13.281

Review 4.  Theranostic nanoparticles for cancer and cardiovascular applications.

Authors:  Dan Wang; Bingbing Lin; Hua Ai
Journal:  Pharm Res       Date:  2014-03-05       Impact factor: 4.200

5.  Cationic Dendrimers for siRNA Delivery: An Overview of Methods for In Vitro/In Vivo Characterization.

Authors:  Erik Laurini; Suzana Aulic; Domenico Marson; Maurizio Fermeglia; Sabrina Pricl
Journal:  Methods Mol Biol       Date:  2021

6.  Clickable Poly(ionic liquids): A Materials Platform for Transfection.

Authors:  Jessica L Freyer; Spencer D Brucks; Graham S Gobieski; Sebastian T Russell; Carrie E Yozwiak; Mengzhen Sun; Zhixing Chen; Yivan Jiang; Jeffrey S Bandar; Brent R Stockwell; Tristan H Lambert; Luis M Campos
Journal:  Angew Chem Int Ed Engl       Date:  2016-08-31       Impact factor: 15.336

7.  Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes.

Authors:  Irene Buzzacchera; Qi Xiao; Hong Han; Khosrow Rahimi; Shangda Li; Nina Yu Kostina; B Jelle Toebes; Samantha E Wilner; Martin Möller; Cesar Rodriguez-Emmenegger; Tobias Baumgart; Daniela A Wilson; Christopher J Wilson; Michael L Klein; Virgil Percec
Journal:  Biomacromolecules       Date:  2018-11-07       Impact factor: 6.988

8.  Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery.

Authors:  Alexander C Eldredge; Mark E Johnson; Nathan J Oldenhuis; Zhibin Guan
Journal:  Biomacromolecules       Date:  2016-09-07       Impact factor: 6.988

9.  Recent advances in targeted drug delivery approaches using dendritic polymers.

Authors:  Jason Bugno; Hao-jui Hsu; Seungpyo Hong
Journal:  Biomater Sci       Date:  2014-12-11       Impact factor: 6.843

10.  Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.

Authors:  Xiaoxuan Liu; Jiehua Zhou; Tianzhu Yu; Chao Chen; Qiang Cheng; Kheya Sengupta; Yuanyu Huang; Haitang Li; Cheng Liu; Yang Wang; Paola Posocco; Menghua Wang; Qi Cui; Suzanne Giorgio; Maurizio Fermeglia; Fanqi Qu; Sabrina Pricl; Yanhong Shi; Zicai Liang; Palma Rocchi; John J Rossi; Ling Peng
Journal:  Angew Chem Int Ed Engl       Date:  2014-09-12       Impact factor: 15.336
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