Jason Bugno1, Hao-jui Hsu, Seungpyo Hong. 1. Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL 60612, USA. sphong@uic.edu.
Abstract
Since they were first synthesized over 30 years ago, dendrimers have seen rapid translation into various biomedical applications. A number of reports have not only demonstrated their clinical utility, but also revealed novel design approaches and strategies based on the elucidation of underlying mechanisms governing their biological interactions. This review focuses on presenting the latest advances in dendrimer design, discussing the current mechanistic understandings, and highlighting recent developments and targeted approaches using dendrimers in drug/gene delivery.
Since they were first synthesized over 30 years ago, dendrimers have seen rapid translation into various biomedical applications. A number of reports have not only demonstrated their clinical utility, but also revealed novel design approaches and strategies based on the elucidation of underlying mechanisms governing their biological interactions. This review focuses on presenting the latest adn class="Disease">vances in denpan>drimer designpan>, discussing the currenpan>t mechanistic understandings, and highlighting recenpan>t developmenpan>ts and targeted approaches using denpan>drimers in drug/genpan>e delivery.
Authors: Lisa M Kaminskas; Victoria M McLeod; Brian D Kelly; Carleen Cullinane; Gian Sberna; Mark Williamson; Ben J Boyd; David J Owen; Christopher J H Porter Journal: Mol Pharm Date: 2012-01-27 Impact factor: 4.939
Authors: Xi Jiang; Jason Bugno; Chao Hu; Yang Yang; Tobias Herold; Jun Qi; Ping Chen; Sandeep Gurbuxani; Stephen Arnovitz; Jennifer Strong; Kyle Ferchen; Bryan Ulrich; Hengyou Weng; Yungui Wang; Hao Huang; Shenglai Li; Mary Beth Neilly; Richard A Larson; Michelle M Le Beau; Stefan K Bohlander; Jie Jin; Zejuan Li; James E Bradner; Seungpyo Hong; Jianjun Chen Journal: Cancer Res Date: 2016-06-08 Impact factor: 12.701