Sunil Unnikrishnan1, Alexander L Klibanov. 1. Cardiovascular Division, Cardiovascular Research Center, and Department of Biomedical Engineering, University of Virginia, MR4 RM3146, 409 Lane Rd, PO Box 800158, Charlottesville, VA 22098, USA.
Abstract
OBJECTIVE: The purpose of this review is to describe trends in microbubble application in molecular imaging. CONCLUSION: Microbubbles are used for contrast ultrasound imaging as blood-pool agents in cardiology and radiology. Their promise as targeted agents for molecular imaging is now being recognized. Microbubbles can be functionalized with ligand molecules that bind to molecular markers of disease. Potential clinical applications of molecular imaging with microbubble-based ultrasound contrast agents are in the monitoring of the biomarker status of vascular endothelium, visualizing tumor vasculature, and imaging inflammation and ischemia-reperfusion injury zones and thrombi.
OBJECTIVE: The purpose of this review is to describe trends in microbubble application in molecular imaging. CONCLUSION: Microbubbles are used for contrast ultrasound imaging as blood-pool agents in cardiology and radiology. Their promise as targeted agents for molecular imaging is now being recognized. Microbubbles can be functionalized with ligand molecules that bind to molecular markers of disease. Potential clinical applications of molecular imaging with microbubble-based ultrasound contrast agents are in the monitoring of the biomarker status of vascular endothelium, visualizing tumor vasculature, and imaging inflammation and ischemia-reperfusion injury zones and thrombi.
Authors: Guillaume Lajoinie; Ine De Cock; Constantin C Coussios; Ine Lentacker; Séverine Le Gac; Eleanor Stride; Michel Versluis Journal: Biomicrofluidics Date: 2016-01-28 Impact factor: 2.800
Authors: Rakesh Bam; Patrick S Lown; Lawrence A Stern; Karina Sharma; Katheryne E Wilson; Gregory R Bean; Amelie M Lutz; Ramasamy Paulmurugan; Benjamin J Hackel; Jeremy Dahl; Lotfi Abou-Elkacem Journal: Clin Cancer Res Date: 2020-01-10 Impact factor: 12.531