BACKGROUND: Many cancer survivors experience declines in health-related quality of life (HRQOL) and increases in fatigue as a result of cancer and its treatment. Exercise is linked to improvements in these outcomes, but little is known about the role of sedentary behavior. In a large, ethnically-diverse cohort of breast cancer survivors, we examined the relationship between sedentary time, HRQOL, and fatigue, and examined if that relationship differed by recreational moderate-vigorous physical activity (MVPA) level. METHODS: Participants were 710 women diagnosed with stage 0-IIIA breast cancer in the Health, Eating, Activity, and Lifestyle Study. Women completed questionnaires at approximately 30-months postdiagnosis (sedentary time; recreational MVPA) and 41-months postdiagnosis (HRQOL; fatigue). In multivariate models, we regressed these outcomes linearly on quartiles of daily sedentary time, and a variable jointly reflecting sedentary time quartiles and MVPA categories (0; >0 to <9; ≥9 MET-hrs/wk). RESULTS: Sedentary time was not independently related to subscales or summary scores of HRQOL or fatigue. In addition, comparisons of women with high vs. low (Q4:Q1) sedentary time by MVPA level did not result in significant differences in HRQOL or fatigue. CONCLUSION: In this breast cancer survivor cohort, self-reported sedentary time was not associated with HRQOL or fatigue, 3.5 years postdiagnosis.
BACKGROUND: Many cancer survivors experience declines in health-related quality of life (HRQOL) and increases in fatigue as a result of cancer and its treatment. Exercise is linked to improvements in these outcomes, but little is known about the role of sedentary behavior. In a large, ethnically-diverse cohort of breast cancer survivors, we examined the relationship between sedentary time, HRQOL, and fatigue, and examined if that relationship differed by recreational moderate-vigorous physical activity (MVPA) level. METHODS:Participants were 710 women diagnosed with stage 0-IIIA breast cancer in the Health, Eating, Activity, and Lifestyle Study. Women completed questionnaires at approximately 30-months postdiagnosis (sedentary time; recreational MVPA) and 41-months postdiagnosis (HRQOL; fatigue). In multivariate models, we regressed these outcomes linearly on quartiles of daily sedentary time, and a variable jointly reflecting sedentary time quartiles and MVPA categories (0; >0 to <9; ≥9 MET-hrs/wk). RESULTS: Sedentary time was not independently related to subscales or summary scores of HRQOL or fatigue. In addition, comparisons of women with high vs. low (Q4:Q1) sedentary time by MVPA level did not result in significant differences in HRQOL or fatigue. CONCLUSION: In this breast cancer survivor cohort, self-reported sedentary time was not associated with HRQOL or fatigue, 3.5 years postdiagnosis.
Authors: Melinda L Irwin; Anne McTiernan; Leslie Bernstein; Frank D Gilliland; Richard Baumgartner; Kathy Baumgartner; Rachel Ballard-Barbash Journal: Med Sci Sports Exerc Date: 2004-09 Impact factor: 5.411
Authors: Anne McTiernan; Kumar B Rajan; Shelley S Tworoger; Melinda Irwin; Leslie Bernstein; Richard Baumgartner; Frank Gilliland; Frank Z Stanczyk; Yutaka Yasui; Rachel Ballard-Barbash Journal: J Clin Oncol Date: 2003-05-15 Impact factor: 44.544
Authors: Siobhan M Phillips; Meir J Stampfer; June M Chan; Edward L Giovannucci; Stacey A Kenfield Journal: J Cancer Surviv Date: 2015-04-16 Impact factor: 4.442
Authors: Sheri J Hartman; Catherine R Marinac; John Bellettiere; Suneeta Godbole; Loki Natarajan; Ruth E Patterson; Jacqueline Kerr Journal: Support Care Cancer Date: 2017-03-22 Impact factor: 3.603
Authors: Laura P Forsythe; Catherine M Alfano; Stephanie M George; Anne McTiernan; Kathy B Baumgartner; Leslie Bernstein; Rachel Ballard-Barbash Journal: Breast Cancer Res Treat Date: 2012-12-15 Impact factor: 4.872
Authors: Siobhan M Phillips; Elizabeth A Awick; David E Conroy; Christine A Pellegrini; Emily L Mailey; Edward McAuley Journal: Cancer Date: 2015-08-26 Impact factor: 6.860
Authors: Brandi T Cuevas; Daniel C Hughes; Dorothy Long Parma; Rose A Treviño-Whitaker; Sagar Ghosh; Rong Li; Amelie G Ramirez Journal: Support Care Cancer Date: 2013-11-19 Impact factor: 3.603