Literature DB >> 22807303

Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.

Jennifer Foulke-Abel1, Craig A Townsend.   

Abstract

The pathway for substrate transacylation between a fungal type I fatty acid synthase (FAS) and a nonreducing polyketide synthase (NR-PKS) was determined by in vitro reconstitution of dissected domains. System kinetics were influenced by domain dissections, and the FAS phosphopantetheinyl transferase (PPT) monodomain exhibited coenzyme A selectivity for the post-translational activation of the FAS acyl carrier protein (ACP).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22807303      PMCID： PMC3516909          DOI： 10.1002/cbic.201200267

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  27 in total

Review 1.  Biosynthesis and attachment of novel bacterial polyketide synthase starter units.

Authors:  Bradley S Moore; Christian Hertweck
Journal:  Nat Prod Rep       Date:  2002-02       Impact factor: 13.423

2.  A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

Authors:  Daniel W Udwary; Matthew Merski; Craig A Townsend
Journal:  J Mol Biol       Date:  2002-10-25       Impact factor: 5.469

3.  Architecture of a fungal fatty acid synthase at 5 A resolution.

Authors:  Simon Jenni; Marc Leibundgut; Timm Maier; Nenad Ban
Journal:  Science       Date:  2006-03-03       Impact factor: 47.728

4.  Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases.

Authors:  L E Quadri; P H Weinreb; M Lei; M M Nakano; P Zuber; C T Walsh
Journal:  Biochemistry       Date:  1998-02-10       Impact factor: 3.162

5.  Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis.

Authors:  T S Hitchman; E W Schmidt; F Trail; M D Rarick; J E Linz; C A Townsend
Journal:  Bioorg Chem       Date:  2001-10       Impact factor: 5.275

6.  Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis.

Authors:  P J Belshaw; C T Walsh; T Stachelhaus
Journal:  Science       Date:  1999-04-16       Impact factor: 47.728

7.  Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.

Authors:  Anna L Vagstad; Stefanie B Bumpus; Katherine Belecki; Neil L Kelleher; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2012-04-09       Impact factor: 15.419

8.  Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid synthases and a polyketide synthase in the biosynthesis of aflatoxin B1.

Authors:  C M Watanabe; D Wilson; J E Linz; C A Townsend
Journal:  Chem Biol       Date:  1996-06

9.  Spontaneous alpha-N-6-phosphogluconoylation of a "His tag" in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins.

Authors:  K F Geoghegan; H B Dixon; P J Rosner; L R Hoth; A J Lanzetti; K A Borzilleri; E S Marr; L H Pezzullo; L B Martin; P K LeMotte; A S McColl; A V Kamath; J G Stroh
Journal:  Anal Biochem       Date:  1999-02-01       Impact factor: 3.365

10.  Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.

Authors:  Michael B Austin; Tamao Saito; Marianne E Bowman; Stephen Haydock; Atsushi Kato; Bradley S Moore; Robert R Kay; Joseph P Noel
Journal:  Nat Chem Biol       Date:  2006-08-13       Impact factor: 15.040
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  13 in total

Review 1.  The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors:  Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal:  Nat Prod Rep       Date:  2014-01       Impact factor: 13.423

Review 2.  The architectures of iterative type I PKS and FAS.

Authors:  Dominik A Herbst; Craig A Townsend; Timm Maier
Journal:  Nat Prod Rep       Date:  2018-10-17       Impact factor: 13.423

3.  Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.

Authors:  Yuquan Xu; Tong Zhou; Shuwei Zhang; Patricia Espinosa-Artiles; Luoyi Wang; Wei Zhang; Min Lin; A A Leslie Gunatilaka; Jixun Zhan; István Molnár
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-21       Impact factor: 11.205

4.  Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.

Authors:  Yuquan Xu; Tong Zhou; Shuwei Zhang; Li-Jiang Xuan; Jixun Zhan; István Molnár
Journal:  J Am Chem Soc       Date:  2013-07-12       Impact factor: 15.419

5.  Stuffed Methyltransferase Catalyzes the Penultimate Step of Pyochelin Biosynthesis.

Authors:  Trey A Ronnebaum; Jeffrey S McFarlane; Thomas E Prisinzano; Squire J Booker; Audrey L Lamb
Journal:  Biochemistry       Date:  2018-12-27       Impact factor: 3.162

6.  Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA.

Authors:  Callie R Huitt-Roehl; Eric A Hill; Martina M Adams; Anna L Vagstad; Jesse W Li; Craig A Townsend
Journal:  ACS Chem Biol       Date:  2015-03-10       Impact factor: 5.100

7.  Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus.

Authors:  Yuquan Xu; Patricia Espinosa-Artiles; Vivien Schubert; Ya-ming Xu; Wei Zhang; Min Lin; A A Leslie Gunatilaka; Roderich Süssmuth; István Molnár
Journal:  Appl Environ Microbiol       Date:  2013-01-18       Impact factor: 4.792

8.  Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons.

Authors:  Jing Bai; Yuanyuan Lu; Ya-ming Xu; Wei Zhang; Ming Chen; Min Lin; A A Leslie Gunatilaka; Yuquan Xu; István Molnár
Journal:  Org Lett       Date:  2016-03-02       Impact factor: 6.005

9.  Rational reprogramming of fungal polyketide first-ring cyclization.

Authors:  Yuquan Xu; Tong Zhou; Zhengfu Zhou; Shiyou Su; Sue A Roberts; William R Montfort; Jia Zeng; Ming Chen; Wei Zhang; Min Lin; Jixun Zhan; István Molnár
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-18       Impact factor: 11.205

10.  The structural organization of substrate loading in iterative polyketide synthases.

Authors:  Dominik A Herbst; Callie R Huitt-Roehl; Roman P Jakob; Jacob M Kravetz; Philip A Storm; Jamie R Alley; Craig A Townsend; Timm Maier
Journal:  Nat Chem Biol       Date:  2018-04-02       Impact factor: 15.040
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