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Literature DB >> 22806561

The EYA-SO/SIX complex in development and disease.

Abstract

Eyes absent (EYA) and Sine oculis (SO/SIX) proteins function as transcriptional activation complexes and play essential roles in organogenesis during embryonic development in regulating cell proliferation and survival and coordination of particular differentiation programs. Mutations of the Eya and So/Six genes cause profound developmental defects in organisms as diverse as flies, frogs, fish, mice, and humans. EYA proteins also possess an intrinsic phosphatase activity, which is essential for normal development. Here, we review crucial roles of EYA and SO/SIX in development and disease in mice and humans.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22806561 PMCID： PMC6592036 DOI： 10.1007/s00467-012-2246-1

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

122 in total

Review 1. A conserved blueprint for the eye?

Authors: J E Treisman
Journal: Bioessays Date: 1999-10 Impact factor: 4.345

2. Homologs of animal eyes absent (eya) genes are found in higher plants.

Authors: Y Takeda; S Hatano; N Sentoku; M Matsuoka
Journal: Mol Gen Genet Date: 1999-08

Review 3. Kidney morphogenesis: cellular and molecular regulation.

Authors: S Kuure; R Vuolteenaho; S Vainio
Journal: Mech Dev Date: 2000-03-15 Impact factor: 1.882

4. Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians.

Authors: D Pineda; J Gonzalez; P Callaerts; K Ikeo; W J Gehring; E Salo
Journal: Proc Natl Acad Sci U S A Date: 2000-04-25 Impact factor: 11.205

5. Mutations of a human homologue of the Drosophila eyes absent gene (EYA1) detected in patients with congenital cataracts and ocular anterior segment anomalies.

Authors: N Azuma; A Hirakiyama; T Inoue; A Asaka; M Yamada
Journal: Hum Mol Genet Date: 2000-02-12 Impact factor: 6.150

6. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.

Authors: Y Miyazaki; K Oshima; A Fogo; B L Hogan; I Ichikawa
Journal: J Clin Invest Date: 2000-04 Impact factor: 14.808

7. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

Authors: H Ohto; S Kamada; K Tago; S I Tominaga; H Ozaki; S Sato; K Kawakami
Journal: Mol Cell Biol Date: 1999-10 Impact factor: 4.272

8. Six class homeobox genes in drosophila belong to three distinct families and are involved in head development.

Authors: H C Seo; J Curtiss; M Mlodzik; A Fjose
Journal: Mech Dev Date: 1999-05 Impact factor: 1.882

9. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.

Authors: P X Xu; J Adams; H Peters; M C Brown; S Heaney; R Maas
Journal: Nat Genet Date: 1999-09 Impact factor: 38.330

10. The zebrafish eya1 gene and its expression pattern during embryogenesis.

Authors: I Sahly; P Andermann; C Petit
Journal: Dev Genes Evol Date: 1999-07 Impact factor: 0.900

24 in total

Review 1. Multiple Functions of the Eya Phosphotyrosine Phosphatase.

Authors: Ilaria Rebay
Journal: Mol Cell Biol Date: 2015-12-14 Impact factor: 4.272

2. Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis.

Authors: Jinshu Xu; Elaine Y M Wong; Chunming Cheng; Jun Li; Mohammad T K Sharkar; Chelsea Y Xu; Binglai Chen; Jianbo Sun; Dongzhu Jing; Pin-Xian Xu
Journal: Dev Cell Date: 2014-11-24 Impact factor: 12.270

Review 3. The application of gene marker-assisted selection and proteomics for the best meat quality criteria and body measurements in Qinchuan cattle breed.

Authors: Mohamed E Abd El-Hack; Sameh A Abdelnour; Ayman A Swelum; Muhammad Arif
Journal: Mol Biol Rep Date: 2018-07-13 Impact factor: 2.316

4. Development: Unique genetic determinants of human kidney development.

Authors: Leif Oxburgh
Journal: Nat Rev Urol Date: 2016-05-10 Impact factor: 14.432

5. EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer.

Authors: Jun Li; Yoel Rodriguez; Chunming Cheng; Lei Zeng; Elaine Y M Wong; Chelsea Y Xu; Ming-Ming Zhou; Pin-Xian Xu
Journal: Mol Cell Biol Date: 2016-12-19 Impact factor: 4.272

6. Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.

Authors: Meng Jin; Sara Aibar; Zhongqi Ge; Rui Chen; Stein Aerts; Graeme Mardon
Journal: Dev Biol Date: 2016-05-10 Impact factor: 3.582

7. MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling.

Authors: Jin Gao; Xiao-Yu Kang; Shen Sun; Li Li; Dian-Shuai Gao
Journal: J Mol Neurosci Date: 2019-11-13 Impact factor: 3.444