STUDY DESIGN: Histological observational study of patients with spinal meningioma. OBJECTIVE: To clarify the status of tumor cell invasion into the dura mater and to provide fundamental information for appropriate management of dural attachment. SUMMARY OF BACKGROUND DATA: Histological appearance of the dura attached to spinal meningioma has not been sufficiently evaluated. METHODS: Dura mater resected in a Simpson Grade 1 manner from 25 consecutive patients with spinal meningiomas (World Health Organization grade 1) was histologically observed to determine the status of tumor cell invasion. As no clear borders such as a tumor capsule between tumor and dura mater were observed, histological findings of the dura mater were classified into the following 3 categories: grade 1, no dural invasion, with only inflammation of the dura; grade 2: dural invasion below the zone between the inner and outer layers; and grade 3, dural invasion into or over the zone between the inner and outer layers (full-thickness invasion). RESULTS: In our microscopic study, 19 of the 25 cases of spinal meningioma showed evidence of dural invasion and 15 cases showed full-thickness invasion. CONCLUSION: This histological investigation of resected dura mater attached to spinal meningioma showed a high rate of full-thickness tumor invasion into the dura mater.
STUDY DESIGN: Histological observational study of patients with spinal meningioma. OBJECTIVE: To clarify the status of tumor cell invasion into the dura mater and to provide fundamental information for appropriate management of dural attachment. SUMMARY OF BACKGROUND DATA: Histological appearance of the dura attached to spinal meningioma has not been sufficiently evaluated. METHODS: Dura mater resected in a Simpson Grade 1 manner from 25 consecutive patients with spinal meningiomas (World Health Organization grade 1) was histologically observed to determine the status of tumor cell invasion. As no clear borders such as a tumor capsule between tumor and dura mater were observed, histological findings of the dura mater were classified into the following 3 categories: grade 1, no dural invasion, with only inflammation of the dura; grade 2: dural invasion below the zone between the inner and outer layers; and grade 3, dural invasion into or over the zone between the inner and outer layers (full-thickness invasion). RESULTS: In our microscopic study, 19 of the 25 cases of spinal meningioma showed evidence of dural invasion and 15 cases showed full-thickness invasion. CONCLUSION: This histological investigation of resected dura mater attached to spinal meningioma showed a high rate of full-thickness tumor invasion into the dura mater.
Authors: Jing Zhuang; Jin Gong; Gary D Hack; Yan-Yan Chi; Yang Song; Sheng-Bo Yu; Hong-Jin Sui Journal: Surg Radiol Anat Date: 2022-06-17 Impact factor: 1.354
Authors: Tao Xu; Yong Yan; Alexander I Evins; Zhenyu Gong; Lei Jiang; Huaiyu Sun; Li Cai; Hongxiang Wang; Weiqing Li; Yicheng Lu; Ming Zhang; Juxiang Chen Journal: Front Oncol Date: 2020-05-25 Impact factor: 6.244