BACKGROUND AND OBJECTIVE: Vitamin D-binding protein (DBP) is a multifunctional and highly expressed plasma protein. Among its diverse roles, including those in the immune and inflammatory responses, it is the primary carrier of vitamin D, which has been implicated in periodontitis. We hypothesized that there is a correlation between systemic DBP levels and generalized aggressive periodontitis (GAgP). MATERIAL AND METHODS: Forty-four patients with GAgP and 32 healthy controls were recruited. Clinical parameters were examined, including the mean bleeding index, probing depth, attachment loss and percentage of severely affected sites. Blood chemistry analyses were performed for each subject. Plasma levels of DBP, interleukin-6 (IL-6) and procalcitonin (PCT) were measured using ELISAs, and plasma levels of 25-hydroxy-vitamin D(3) (25(OH)D(3)) were detected using a radioimmunoassay. RESULTS: Significantly higher levels of plasma DBP, IL-6, PCT and 25(OH)D(3), as well as leukocyte counts, neutrophil counts and neutrophil percentages were found in patients with GAgP compared with healthy controls (p < 0.05 for all). Multiple linear regression analysis showed that the plasma DBP levels were significantly correlated with GAgP, plasma PCT levels and smoking status (p < 0.05 for all). In the GAgP group, the plasma DBP levels in smokers were significantly higher than those in nonsmokers (p < 0.001). CONCLUSION: Elevated plasma vitamin DBP levels are associated with GAgP.
BACKGROUND AND OBJECTIVE:Vitamin D-binding protein (DBP) is a multifunctional and highly expressed plasma protein. Among its diverse roles, including those in the immune and inflammatory responses, it is the primary carrier of vitamin D, which has been implicated in periodontitis. We hypothesized that there is a correlation between systemic DBP levels and generalized aggressive periodontitis (GAgP). MATERIAL AND METHODS: Forty-four patients with GAgP and 32 healthy controls were recruited. Clinical parameters were examined, including the mean bleeding index, probing depth, attachment loss and percentage of severely affected sites. Blood chemistry analyses were performed for each subject. Plasma levels of DBP, interleukin-6 (IL-6) and procalcitonin (PCT) were measured using ELISAs, and plasma levels of 25-hydroxy-vitamin D(3) (25(OH)D(3)) were detected using a radioimmunoassay. RESULTS: Significantly higher levels of plasma DBP, IL-6, PCT and 25(OH)D(3), as well as leukocyte counts, neutrophil counts and neutrophil percentages were found in patients with GAgP compared with healthy controls (p < 0.05 for all). Multiple linear regression analysis showed that the plasma DBP levels were significantly correlated with GAgP, plasma PCT levels and smoking status (p < 0.05 for all). In the GAgP group, the plasma DBP levels in smokers were significantly higher than those in nonsmokers (p < 0.001). CONCLUSION: Elevated plasma vitamin DBP levels are associated with GAgP.
Authors: R S Redman; G S Kerr; J B Payne; T R Mikuls; J Huang; H R Sayles; K L Becker; E S Nylén Journal: Biotech Histochem Date: 2016 Impact factor: 1.718
Authors: Angela Pia Cazzolla; Michele Di Cosola; Andrea Ballini; Luigi Santacroce; Roberto Lovero; Nunzio Francesco Testa; Vitantonio Lacarbonara; Annarosa De Franco; Giuseppe Troiano; Stefania Cantore; Mariasevera Di Comite; Riccardo Nocini; Lorenzo Lo Muzio; Vito Crincoli; Mario Dioguardi Journal: Biomed Res Int Date: 2021-10-29 Impact factor: 3.411
Authors: Abdullah Ali H Alzahrani; Raed A Alharbi; Mohammed Sarhan A Alzahrani; Mohammed A Sindi; Ghalia Shamlan; Faisal A Alzahrani; Mohammad A Albanghali; Abdulmajeed Abdulghani A Sindi Journal: Saudi J Biol Sci Date: 2021-04-20 Impact factor: 4.052