| Literature DB >> 22800913 |
Fei-xia Huang1, Wen-zhi Yang, Fei Ye, Jin-ying Tian, Hong-bo Hu, Lin-min Feng, De-an Guo, Min Ye.
Abstract
Biotransformation of ursolic acid by the filamentous fungus Syncephalastrum racemosum (Cohn) Schroter AS 3.264 yielded five metabolites. Their structures were identified as 3β,21β-dihydroxy-urs-11-en-28-oic acid-13-lactone, 3β,7β,21β-trihydroxy-urs-11-en-28-oic acid-13-lactone, 1β,3β-dihydroxy-urs-12-en-21-one-28-oic acid, 1β,3β,21β-trihydroxy-urs-12-en-28-oic acid and 11,26-epoxy-3β,21β-dihydroxy-urs-12-en-28-oic acid based on NMR and MS spectroscopic analyses. The condensation reactions to form 28-oic acid-13-lactone ring and 11,26-epoxy ring are not frequently seen for the biotransformation of triterpenoids. One compound showed moderate inhibitory activity against protein tyrosine phosphatase 1B (PTP1B).Entities:
Mesh：
Substances：
Year: 2012 PMID： 22800913 DOI： 10.1016/j.phytochem.2012.06.020
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072