OBJECTIVE: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women. METHODS AND MATERIALS: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests. RESULTS: We found no association between the two polymorphic sites of interleukin-1β gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the AvaI polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5. CONCLUSION: Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women.
OBJECTIVE: To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women. METHODS AND MATERIALS: We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests. RESULTS: We found no association between the two polymorphic sites of interleukin-1β gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the AvaI polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5. CONCLUSION: Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women.
Authors: José Pacheco-Romero; Oscar Acosta; Doris Huerta; Santiago Cabrera; Marlene Vargas; Pedro Mascaro; Moisés Huamán; José Sandoval; Rudy López; Julio Mateus; Enrique Gil; Enrique Guevara; Nitza Butrica; Diana Catari; David Bellido; Gina Custodio; Andrea Naranjo Journal: Colomb Med (Cali) Date: 2021-02-26
Authors: Hameed M Hamid; Sana E Abdalla; Mohamed Sidig; Ishag Adam; Hamdan Z Hamdan Journal: Mol Genet Genomic Med Date: 2020-01-14 Impact factor: 2.183