Literature DB >> 22790208

Molecular mechanisms of external genitalia development.

Sarah D Blaschko1, Gerald R Cunha, Laurence S Baskin.   

Abstract

External genitalia development occurs through a combination of hormone independent, hormone dependent, and endocrine pathways. Perturbation of these pathways can lead to abnormal external genitalia development. We review human and animal mechanisms of normal and abnormal external genitalia development, and we evaluate abnormal mechanisms that lead to hypospadias. We also discuss recent laboratory findings that further our understanding of animal models of hypospadias.
Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22790208      PMCID： PMC3443292          DOI： 10.1016/j.diff.2012.06.003

Source DB:  PubMed          Journal:  Differentiation        ISSN： 0301-4681            Impact factor:   3.880


  78 in total

1.  Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat.

Authors:  L E Gray; J Ostby; E Monosson; W R Kelce
Journal:  Toxicol Ind Health       Date:  1999 Jan-Mar       Impact factor: 2.273

2.  Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat.

Authors:  C Wolf; C Lambright; P Mann; M Price; R L Cooper; J Ostby; L E Gray
Journal:  Toxicol Ind Health       Date:  1999 Jan-Mar       Impact factor: 2.273

3.  DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita.

Authors:  M Ito; R Yu; J L Jameson
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

4.  Androgenicity in the rat fetus of metabolites of testosterone and antagonism by cyproterone acetate.

Authors:  A S Goldman; M K Baker
Journal:  Endocrinology       Date:  1971-07       Impact factor: 4.736

5.  Development of the mammalian urethra is controlled by Fgfr2-IIIb.

Authors:  Anita Petiot; Claire L Perriton; Clive Dickson; Martin J Cohn
Journal:  Development       Date:  2005-04-20       Impact factor: 6.868

6.  CHARGE syndrome includes hypogonadotropic hypogonadism and abnormal olfactory bulb development.

Authors:  G Pinto; V Abadie; R Mesnage; J Blustajn; S Cabrol; J Amiel; L Hertz-Pannier; A M Bertrand; S Lyonnet; R Rappaport; I Netchine
Journal:  J Clin Endocrinol Metab       Date:  2005-07-19       Impact factor: 5.958

7.  Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors.

Authors:  Yoshihiko Satoh; Ryuma Haraguchi; Tracy J Wright; Suzanne L Mansour; Juha Partanen; Mohammad K Hajihosseini; Veraragavan P Eswarakumar; Peter Lonai; Gen Yamada
Journal:  Anat Embryol (Berl)       Date:  2004-08-31

8.  Role of gonadal hormones in development of the sexual phenotypes.

Authors:  J D Wilson; J E Griffin; M Leshin; F W George
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

9.  A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.

Authors:  A H Sinclair; P Berta; M S Palmer; J R Hawkins; B L Griffiths; M J Smith; J W Foster; A M Frischauf; R Lovell-Badge; P N Goodfellow
Journal:  Nature       Date:  1990-07-19       Impact factor: 49.962

10.  Decrease in anogenital distance among male infants with prenatal phthalate exposure.

Authors:  Shanna H Swan; Katharina M Main; Fan Liu; Sara L Stewart; Robin L Kruse; Antonia M Calafat; Catherine S Mao; J Bruce Redmon; Christine L Ternand; Shannon Sullivan; J Lynn Teague
Journal:  Environ Health Perspect       Date:  2005-08       Impact factor: 9.031
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  27 in total

1.  Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation.

Authors:  Kentaro Suzuki; Tomokazu Numata; Hiroko Suzuki; Dennis Diana Raga; Lerrie Ann Ipulan; Chikako Yokoyama; Shoko Matsushita; Michito Hamada; Naomi Nakagata; Ryuichi Nishinakamura; Shoen Kume; Satoru Takahashi; Gen Yamada
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-31       Impact factor: 11.205

2.  A critical role for estrogen signaling in penis development.

Authors:  Luke C Govers; Tiffany R Phillips; Deidre M Mattiske; Nineveh Rashoo; Jay R Black; Adriane Sinclair; Laurence S Baskin; Gail P Risbridger; Andrew J Pask
Journal:  FASEB J       Date:  2019-06-21       Impact factor: 5.191

Review 3.  The power and perils of animal models with urogenital anomalies: handle with care.

Authors:  J M Hutson; L S Baskin; G Risbridger; G R Cunha
Journal:  J Pediatr Urol       Date:  2014-04-12       Impact factor: 1.830

Review 4.  Engineering epithelial-stromal interactions in vitro for toxicology assessment.

Authors:  David G Belair; Barbara D Abbott
Journal:  Toxicology       Date:  2017-03-08       Impact factor: 4.221

5.  Association of SRD5A2 gene mutations with risk of hypospadias in the Iranian population.

Authors:  M Rahimi; M Ghanbari; Z Fazeli; M Rouzrokh; S Omrani; R Mirfakhraie; M D Omrani
Journal:  J Endocrinol Invest       Date:  2016-11-15       Impact factor: 4.256

6.  A Comprehensive Atlas of the Adult Mouse Penis.

Authors:  Tiffany R Phillips; David K Wright; Paul E Gradie; Leigh A Johnston; Andrew J Pask
Journal:  Sex Dev       Date:  2015-06-19       Impact factor: 1.824

7.  Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10.5-E18.5.

Authors:  Susan A Elmore; Sanam L Kavari; Mark J Hoenerhoff; Beth Mahler; Brittany E Scott; Koichi Yabe; John C Seely
Journal:  Toxicol Pathol       Date:  2019-10-10       Impact factor: 1.902

8.  Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus.

Authors:  Chris Armoskus; Thomas Mota; Debbie Moreira; Houng-Wei Tsai
Journal:  J Steroids Horm Sci       Date:  2014-07-23

Review 9.  The Genetic and Environmental Factors Underlying Hypospadias.

Authors:  Aurore Bouty; Katie L Ayers; Andrew Pask; Yves Heloury; Andrew H Sinclair
Journal:  Sex Dev       Date:  2015-11-28       Impact factor: 1.824

10.  Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts.

Authors:  Chaoshe Guo; Ye Sun; Chunming Guo; Bryan T MacDonald; Joseph G Borer; Xue Li
Journal:  Dev Biol       Date:  2014-01-01       Impact factor: 3.582
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