Literature DB >> 22789532

Sensitizing cancer cells: is it really all about U?

Patrick J Stover1, Robert S Weiss.   

Abstract

In this issue of Cancer Cell, Hu et al. report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged DNA and produce nucleotides necessary for DNA repair while suppressing uracil incorporation. TMPK inhibition disrupts this balance and selectively sensitizes cancer cells to low-dose chemotherapy.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22789532      PMCID： PMC4939884          DOI： 10.1016/j.ccr.2012.06.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.

Authors:  Hiroyuki Niida; Yuko Katsuno; Misuzu Sengoku; Midori Shimada; Megumi Yukawa; Masae Ikura; Tsuyoshi Ikura; Kazuteru Kohno; Hiroki Shima; Hidekazu Suzuki; Satoshi Tashiro; Makoto Nakanishi
Journal:  Genes Dev       Date:  2010-02-15       Impact factor: 11.361

2.  Intracellular location of thymidylate synthase and its state of phosphorylation.

Authors:  W A Samsonoff; J Reston; M McKee; B O'Connor; J Galivan; G Maley; F Maley
Journal:  J Biol Chem       Date:  1997-05-16       Impact factor: 5.157

3.  Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.

Authors:  Donald D Anderson; Collynn F Woeller; En-Pei Chiang; Barry Shane; Patrick J Stover
Journal:  J Biol Chem       Date:  2012-01-10       Impact factor: 5.157

4.  Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.

Authors:  B C Blount; M M Mack; C M Wehr; J T MacGregor; R A Hiatt; G Wang; S N Wickramasinghe; R B Everson; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

5.  Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage.

Authors:  Yen-Ling Chen; Staffan Eriksson; Zee-Fen Chang
Journal:  J Biol Chem       Date:  2010-06-16       Impact factor: 5.157

Review 6.  5-fluorouracil: mechanisms of action and clinical strategies.

Authors:  Daniel B Longley; D Paul Harkin; Patrick G Johnston
Journal:  Nat Rev Cancer       Date:  2003-05       Impact factor: 60.716

7.  Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status.

Authors:  Chun-Mei Hu; Zee-Fen Chang
Journal:  Cancer Res       Date:  2008-04-15       Impact factor: 12.701

8.  Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.

Authors:  Vincenzo D'Angiolella; Valerio Donato; Frances M Forrester; Yeon-Tae Jeong; Claudia Pellacani; Yasusei Kudo; Anita Saraf; Laurence Florens; Michael P Washburn; Michele Pagano
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

9.  Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

Authors:  Giovanna Pontarin; Artur Fijolek; Paola Pizzo; Paola Ferraro; Chiara Rampazzo; Tullio Pozzan; Lars Thelander; Peter A Reichard; Vera Bianchi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-07       Impact factor: 11.205
  9 in total
  3 in total

Review 1.  Serine, glycine and one-carbon units: cancer metabolism in full circle.

Authors:  Jason W Locasale
Journal:  Nat Rev Cancer       Date:  2013-07-04       Impact factor: 60.716

2.  The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA.

Authors:  Judith R Alonzo; Chantel Venkataraman; Martha S Field; Patrick J Stover
Journal:  J Biol Chem       Date:  2018-11-01       Impact factor: 5.157

Review 3.  A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.

Authors:  Vincenzo D'Angiolella; Mine Esencay; Michele Pagano
Journal:  Trends Cell Biol       Date:  2012-11-19       Impact factor: 20.808
  3 in total

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