Literature DB >> 22788584

Conjunctival limbal autograft and allograft transplantation using fibrin glue.

Jeffrey D Welder1, Hemang K Pandya, Nariman Nassiri, Ali R Djalilian.   

Abstract

BACKGROUND AND
OBJECTIVE: Conjunctival limbal autograft is the surgical treatment of choice for visually significant unilateral limbal stem cell deficiency. The use of fibrin glue, which has been reported extensively in pterygium and other conjunctival surgeries, has not been fully described in limbal stem cell transplantation. PATIENTS AND METHODS: The authors reviewed 3 cases of conjunctival limbal autograft and 1 of living related conjunctival limbal allograft using only fibrin glue to secure the graft. Main outcome measures included ocular surface stability, visual acuity, and postoperative complications.
RESULTS: At most recent follow-up, all 4 patients (100%) maintained a stable ocular surface. Mean epithelial healing time was 10 days. Mean visual acuity improved from 20/400 to 20/53. All grafts were successful with no postoperative dislocations or displacements.
CONCLUSION: The findings demonstrate that fibrin glue can be used safely and effectively to secure conjunctival limbal grafts in limbal stem cell deficiency. This novel approach has the potential to decrease operative time, increase ease of technique, and improve patient comfort postoperatively. Copyright 2012, SLACK Incorporated.

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Year:  2012        PMID: 22788584     DOI: 10.3928/15428877-20120618-04

Source DB:  PubMed          Journal:  Ophthalmic Surg Lasers Imaging        ISSN: 1542-8877


  10 in total

1.  Fibrin glue inhibits migration of ocular surface epithelial cells.

Authors:  A M Yeung; L A Faraj; O D McIntosh; V K Dhillon; H S Dua
Journal:  Eye (Lond)       Date:  2016-07-01       Impact factor: 3.775

2.  Surgical Reconstruction of Ocular Surface Tumors Using Fibrin Sealant Tissue Adhesive.

Authors:  Aline Roseane Queiroz de Paiva; Larissa Abreu de Azevedo Fraga; Virgínia Laura Lucas Torres
Journal:  Ocul Oncol Pathol       Date:  2016-03-15

Review 3.  Strategies for reconstructing the limbal stem cell niche.

Authors:  Ghasem Yazdanpanah; Zeeshan Haq; Kai Kang; Sayena Jabbehdari; Mark L Rosenblatt; Ali R Djalilian
Journal:  Ocul Surf       Date:  2019-01-08       Impact factor: 5.033

Review 4.  Current and Upcoming Therapies for Ocular Surface Chemical Injuries.

Authors:  Alireza Baradaran-Rafii; Medi Eslani; Zeeshan Haq; Ebrahim Shirzadeh; Michael J Huvard; Ali R Djalilian
Journal:  Ocul Surf       Date:  2016-09-17       Impact factor: 5.033

5.  Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency.

Authors:  Alexandra Norrick; Jasmina Esterlechner; Elke Niebergall-Roth; Markus H Frank; Mark A Kluth; Ulf Dehio; Samar Sadeghi; Hannes M Schröder; Seda Ballikaya; Nicole Stemler; Christoph Ganss; Kathrin Dieter; Ann-Kathrin Dachtler; Patrick Merz; Saadettin Sel; James Chodosh; Claus Cursiefen; Natasha Y Frank; Gerd U Auffarth; Bruce Ksander
Journal:  Stem Cell Res Ther       Date:  2021-03-19       Impact factor: 6.832

6.  Fibrin-Plasma Rich in Growth Factors Membrane for the Treatment of a Rabbit Alkali-Burn Lesion.

Authors:  Ronald M Sánchez-Ávila; Natalia Vázquez; Manuel Chacón; Mairobi Persinal-Medina; Agustín Brea-Pastor; Silvia Berisa-Prado; Luis Fernández-Vega-Cueto; Eduardo Anitua; Álvaro Meana; Jesús Merayo-Lloves
Journal:  Int J Mol Sci       Date:  2021-05-25       Impact factor: 5.923

Review 7.  Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive-a Laboratory and Clinical Perspective.

Authors:  William D Spotnitz
Journal:  ISRN Surg       Date:  2014-03-04

Review 8.  Transforming ocular surface stem cell research into successful clinical practice.

Authors:  Virender S Sangwan; Rajat Jain; Sayan Basu; Anupam B Bagadi; Shraddha Sureka; Indumathi Mariappan; Sheila Macneil
Journal:  Indian J Ophthalmol       Date:  2014-01       Impact factor: 1.848

Review 9.  The ocular surface chemical burns.

Authors:  Medi Eslani; Alireza Baradaran-Rafii; Asadolah Movahedan; Ali R Djalilian
Journal:  J Ophthalmol       Date:  2014-07-01       Impact factor: 1.909

Review 10.  The Limbal Niche and Regenerative Strategies.

Authors:  Sohil Amin; Elmira Jalilian; Eitan Katz; Charlie Frank; Ghasem Yazdanpanah; Victor H Guaiquil; Mark I Rosenblatt; Ali R Djalilian
Journal:  Vision (Basel)       Date:  2021-09-22
  10 in total

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