| Literature DB >> 22775397 |
Jian-Xin Yu1, Weina Cui, Vincent A Bourke, Ralph P Mason.
Abstract
pH plays an important role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy, and accurate noninvasive assessment of tumor pH promises to provide insight into developmental processes and prognostic information. In this paper, we report the design, synthesis, and characterization of two novel pH indicators 6-trifluoromethylpyridoxine 8 and α(4),α(5)-di-O-[3'-O-(β-d-glucopyranosyl)propyl]-6-trifluoromethylpyridoxine 17 and demonstrate 8 as an extracellular (19)F NMR pH probe to assess pH(e) of various tumors in vivo.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22775397 PMCID： PMC3430128 DOI： 10.1021/jm300520q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446