Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome.

Literature DB >> 22773728

Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome.

Qin Lan¹, Xiaohui Zhou, Huimin Fan, Maogen Chen, Julie Wang, Bernhard Ryffel, David Brand, Rajalakshmy Ramalingam, Pawel R Kiela, David A Horwitz, Zhongmin Liu, Song Guo Zheng.

Abstract

Interplay between Foxp3(+) regulatory T cells (Treg) and dendritic cells (DCs) maintains immunologic tolerance, but the effects of each cell on the other are not well understood. We report that polyclonal CD4(+)Foxp3(+) Treg cells induced ex vivo with transforming growth factor beta (TGFβ) (iTreg) suppress a lupus-like chronic graft-versus-host disease by preventing the expansion of immunogenic DCs and inducing protective DCs that generate additional recipient CD4(+)Foxp3(+) cells. The protective effects of the transferred iTreg cells required both interleukin (IL)-10 and TGFβ, but the tolerogenic effects of the iTreg on DCs, and the immunosuppressive effects of these DCs were exclusively TGFβ-dependent. The iTreg were unable to tolerize Tgfbr2-deficient DCs. These results support the essential role of DCs in 'infectious tolerance' and emphasize the central role of TGFβ in protective iTreg/DC interactions in vivo.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22773728 PMCID： PMC3523557 DOI： 10.1093/jmcb/mjs040

Source DB: PubMed Journal: J Mol Cell Biol ISSN： 1759-4685 Impact factor: 6.216

51 in total

Review 1. Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.

Authors: Stephen P Cobbold; Elizabeth Adams; Kathleen F Nolan; Frederico S Regateiro; Herman Waldmann
Journal: Immunol Rev Date: 2010-07 Impact factor: 12.988

2. Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot.

Authors: Xiaohui Zhou; Julie Wang; Wei Shi; David D Brand; Zhongmin Liu; Huimin Fan; Song Guo Zheng
Journal: J Mol Cell Biol Date: 2010-04-29 Impact factor: 6.216

3. Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

Authors: Stephen P Cobbold; Elizabeth Adams; Claire A Farquhar; Kathleen F Nolan; Duncan Howie; Kathy O Lui; Paul J Fairchild; Andrew L Mellor; David Ron; Herman Waldmann
Journal: Proc Natl Acad Sci U S A Date: 2009-06-30 Impact factor: 11.205

4. Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu.

Authors: Xiaohui Zhou; Ning Kong; Julie Wang; Huiming Fan; Hejian Zou; David Horwitz; David Brand; Zhongmin Liu; Song Guo Zheng
Journal: J Immunol Date: 2010-08-02 Impact factor: 5.422

5. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

Authors: David Favre; Jeff Mold; Peter W Hunt; Bittoo Kanwar; P'ng Loke; Lillian Seu; Jason D Barbour; Margaret M Lowe; Anura Jayawardene; Francesca Aweeka; Yong Huang; Daniel C Douek; Jason M Brenchley; Jeffrey N Martin; Frederick M Hecht; Steven G Deeks; Joseph M McCune
Journal: Sci Transl Med Date: 2010-05-19 Impact factor: 17.956

6. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Authors: Angela M Thornton; Patricia E Korty; Dat Q Tran; Elizabeth A Wohlfert; Patrick E Murray; Yasmine Belkaid; Ethan M Shevach
Journal: J Immunol Date: 2010-02-24 Impact factor: 5.422

7. Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.

Authors: Dat Q Tran; John Andersson; Donna Hardwick; Lolita Bebris; Gabor G Illei; Ethan M Shevach
Journal: Blood Date: 2009-03-18 Impact factor: 22.113

8. Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD.

Authors: Christian Koenecke; Niklas Czeloth; Anja Bubke; Susanne Schmitz; Adrien Kissenpfennig; Bernard Malissen; Jochen Huehn; Arnold Ganser; Reinhold Förster; Immo Prinz
Journal: Eur J Immunol Date: 2009-11 Impact factor: 5.532

9. Myelin-reactive, TGF-β-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo.

Authors: Richard A O'Connor; Melanie D Leech; Janine Suffner; Günter J Hämmerling; Stephen M Anderton
Journal: J Immunol Date: 2010-11-17 Impact factor: 5.422

10. Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.

Authors: Ling Lu; Xiaohui Zhou; Julie Wang; Song Guo Zheng; David A Horwitz
Journal: PLoS One Date: 2010-12-17 Impact factor: 3.240

42 in total

1. TGF-β-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells.

Authors: Jian Gu; Ling Lu; Maogen Chen; Lili Xu; Qin Lan; Qiang Li; Zhongmin Liu; Guihua Chen; Ping Wang; Xuehao Wang; David Brand; Nancy Olsen; Song Guo Zheng
Journal: J Immunol Date: 2014-08-25 Impact factor: 5.422

2. Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells.

Authors: Ya Liu; Qin Lan; Ling Lu; Maogen Chen; Zanxian Xia; Jilin Ma; Julie Wang; Huimin Fan; Yi Shen; Bernhard Ryffel; David Brand; Francisco Quismorio; Zhongmin Liu; David A Horwitz; Anping Xu; Song Guo Zheng
Journal: J Mol Cell Biol Date: 2013-07-15 Impact factor: 6.216

3. Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?

Authors: Song Guo Zheng
Journal: Am J Clin Exp Immunol Date: 2013-02-27

Review 4. Regulatory T cells and B cells: implication on autoimmune diseases.

Authors: Ping Wang; Song Guo Zheng
Journal: Int J Clin Exp Pathol Date: 2013-11-15

5. Suppression of Murine Lupus by CD4+ and CD8+ Treg Cells Induced by T Cell-Targeted Nanoparticles Loaded With Interleukin-2 and Transforming Growth Factor β.

Authors: David A Horwitz; Sean Bickerton; Michael Koss; Tarek M Fahmy; Antonio La Cava
Journal: Arthritis Rheumatol Date: 2019-03-05 Impact factor: 10.995

6. The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells.

Authors: Wenru Su; Xiaoqing Chen; Wenjie Zhu; Jianfeng Yu; Weihua Li; Yingqi Li; Zhuang Li; Nancy Olsen; Dan Liang; Song Guo Zheng
Journal: J Immunol Date: 2019-08-16 Impact factor: 5.422

7. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.

Authors: Yayi Gao; Jiayou Tang; Weiqian Chen; Qiang Li; Jia Nie; Fang Lin; Qingsi Wu; Zuojia Chen; Zhimei Gao; Huimin Fan; Andy Tsun; Jijia Shen; Guihua Chen; Zhongmin Liu; Zhenkun Lou; Nancy J Olsen; Song Guo Zheng; Bin Li
Journal: Proc Natl Acad Sci U S A Date: 2015-06-09 Impact factor: 11.205