Literature DB >> 23885327

Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?

Song Guo Zheng1.   

Abstract

Naive CD4(+) cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3(+) regulatory T cells depending upon the presence of other cytokines. IL-6 promotes Th17, but suppresses regulatory T cell differentiation. Moreover, natural but not TGF-β-induced regulatory T cells convert into Th17 cells in the inflammatory milieu. Here an update of T cell differentiation and conversion, as well as underlying mechanisms are given.

Entities:  

Keywords:  Foxp3+ regulatory T cells; T helper cells; Tfh; Th1; Th17; Th2; Th9; autoimmunity; cytokine; differentiation

Year:  2013        PMID： 23885327      PMCID： PMC3714204     

Source DB:  PubMed          Journal:  Am J Clin Exp Immunol


  102 in total

1.  Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo.

Authors:  Abdelilah Wakkach; Nathalie Fournier; Valérie Brun; Jean-Philippe Breittmayer; Françoise Cottrez; Hervé Groux
Journal:  Immunity       Date:  2003-05       Impact factor: 31.745

2.  Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.

Authors:  Marc Panzer; Selina Sitte; Stefanie Wirth; Ingo Drexler; Tim Sparwasser; David Voehringer
Journal:  J Immunol       Date:  2011-12-07       Impact factor: 5.422

3.  Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot.

Authors:  Xiaohui Zhou; Julie Wang; Wei Shi; David D Brand; Zhongmin Liu; Huimin Fan; Song Guo Zheng
Journal:  J Mol Cell Biol       Date:  2010-04-29       Impact factor: 6.216

4.  Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

Authors:  R K Gershon; K Kondo
Journal:  Immunology       Date:  1970-05       Impact factor: 7.397

5.  Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Authors:  Angela M Thornton; Patricia E Korty; Dat Q Tran; Elizabeth A Wohlfert; Patrick E Murray; Yasmine Belkaid; Ethan M Shevach
Journal:  J Immunol       Date:  2010-02-24       Impact factor: 5.422

6.  Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

Authors:  M C Fantini; C Becker; I Tubbe; A Nikolaev; H A Lehr; P Galle; M F Neurath
Journal:  Gut       Date:  2005-09-14       Impact factor: 23.059

7.  Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.

Authors:  Satya P Singh; Hongwei H Zhang; John F Foley; Michael N Hedrick; Joshua M Farber
Journal:  J Immunol       Date:  2008-01-01       Impact factor: 5.422

8.  Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.

Authors:  Sarah E Allan; Sarah Q Crome; Natasha K Crellin; Laura Passerini; Theodore S Steiner; Rosa Bacchetta; Maria G Roncarolo; Megan K Levings
Journal:  Int Immunol       Date:  2007-02-27       Impact factor: 4.823

9.  Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.

Authors:  Mahesh Yadav; Cedric Louvet; Dan Davini; James M Gardner; Marc Martinez-Llordella; Samantha Bailey-Bucktrout; Bryan A Anthony; Francis M Sverdrup; Richard Head; Daniel J Kuster; Peter Ruminski; David Weiss; David Von Schack; Jeffrey A Bluestone
Journal:  J Exp Med       Date:  2012-09-10       Impact factor: 14.307

10.  Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.

Authors:  WanJun Chen; Wenwen Jin; Neil Hardegen; Ke-Jian Lei; Li Li; Nancy Marinos; George McGrady; Sharon M Wahl
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
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  31 in total

1.  Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters.

Authors:  Ricardo da Silva Antunes; Mariana Babor; Chelsea Carpenter; Natalie Khalil; Mario Cortese; Alexander J Mentzer; Grégory Seumois; Christopher D Petro; Lisa A Purcell; Pandurangan Vijayanand; Shane Crotty; Bali Pulendran; Bjoern Peters; Alessandro Sette
Journal:  J Clin Invest       Date:  2018-08-06       Impact factor: 14.808

2.  APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients.

Authors:  Ariana Barberá; Noraylis Lorenzo; Peter van Kooten; Joel van Roon; Wilco de Jager; Dinorah Prada; Jorge Gómez; Gabriel Padrón; Willem van Eden; Femke Broere; María Del Carmen Domínguez
Journal:  Cell Stress Chaperones       Date:  2016-05-30       Impact factor: 3.667

Review 3.  Treg cells: a potential regulator for IL-22 expression?

Authors:  Shuman Lin; Xuyan Yang; Dian Liang; Song Guo Zheng
Journal:  Int J Clin Exp Pathol       Date:  2014-01-15

Review 4.  Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.

Authors:  Kenneth S Rosenthal; Katalin Mikecz; Harold L Steiner; Tibor T Glant; Alison Finnegan; Roy E Carambula; Daniel H Zimmerman
Journal:  Expert Rev Vaccines       Date:  2015-03-18       Impact factor: 5.217

Review 5.  Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection.

Authors:  Jie Zhang; Huan Liu; Bin Wei
Journal:  J Zhejiang Univ Sci B       Date:  2017 Apr.       Impact factor: 3.066

Review 6.  The guiding role of bone metabolism test in osteoporosis treatment.

Authors:  Wei Zhang; Guo-Ji Yang; Shi-Xian Wu; Dong-Qing Li; Ying-Bo Xu; Cheng-Hong Ma; Jun-Ling Wang; Wei-Wen Chen
Journal:  Am J Clin Exp Immunol       Date:  2018-04-05

Review 7.  Immune responses in neonates.

Authors:  Saleem Basha; Naveen Surendran; Michael Pichichero
Journal:  Expert Rev Clin Immunol       Date:  2014-08-04       Impact factor: 4.473

Review 8.  Chronic infection by Leishmania amazonensis mediated through MAPK ERK mechanisms.

Authors:  Pedro A Martinez; Christine A Petersen
Journal:  Immunol Res       Date:  2014-08       Impact factor: 2.829

9.  Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses.

Authors:  Ricardo da Silva Antunes; Lorenzo G Quiambao; Ferran Soldevila; Aaron Sutherland; Bjoern Peters; Alessandro Sette
Journal:  Cytokine       Date:  2020-09-29       Impact factor: 3.861

10.  Sublingual immunotherapy increases Treg/Th17 ratio in allergic rhinitis.

Authors:  Jiarong Wang; Liansheng Qiu; Yimin Chen; Minyun Chen
Journal:  Open Med (Wars)       Date:  2021-05-21
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