Imran H Iftikhar1, Robert P Blankfield. 1. School of Medicine, University of South Carolina, Columbia, SC, USA. Imran.Iftikhar@uscmed.sc.edu
Abstract
BACKGROUND: There is little conclusive data regarding the effect of continuous positive airway pressure (CPAP) on glycated hemoglobin (HbA(1c)). An earlier meta-analysis included two randomized controlled trials (RCTs) and found no significant effect of CPAP on HbA(1c). The meta-analysis presented here was conducted to include all relevant observational studies and RCTs on the effect of CPAP on HbA(1c). METHODS: We searched the PubMed database for all studies published prior to March 2012 for trials of the effect of CPAP on HbA(1c). Data from observational studies and RCTs that met the inclusion criteria were extracted for pre- and post-treatment HbA(1c). RESULTS: A total of nine studies that included 151 subjects met the inclusion criteria. The duration of the studies ranged from 41 days to 6 months. The mean net change in the HbA(1c) was -0.06 % [95 % CI: -0.24, 0.12] (p = 0.5). Five of the nine studies, with a total of 112 subjects, comprised patients with diabetes mellitus (DM) type 2. The mean net change in HbA(1c) for the subjects with DM type 2 was 0.08 % [95 % CI: -0.26, 0.42] (p = 0.65). The mean net change in HbA(1c) for subjects with DM type 2 in studies that were at least 3 months in duration was 0.16 % [95 % CI: -0.26, 0.58] (p = 0.45). CONCLUSIONS: This meta-analysis found that CPAP does not reduce HbA(1c) levels when used in the short term.
BACKGROUND: There is little conclusive data regarding the effect of continuous positive airway pressure (CPAP) on glycated hemoglobin (HbA(1c)). An earlier meta-analysis included two randomized controlled trials (RCTs) and found no significant effect of CPAP on HbA(1c). The meta-analysis presented here was conducted to include all relevant observational studies and RCTs on the effect of CPAP on HbA(1c). METHODS: We searched the PubMed database for all studies published prior to March 2012 for trials of the effect of CPAP on HbA(1c). Data from observational studies and RCTs that met the inclusion criteria were extracted for pre- and post-treatment HbA(1c). RESULTS: A total of nine studies that included 151 subjects met the inclusion criteria. The duration of the studies ranged from 41 days to 6 months. The mean net change in the HbA(1c) was -0.06 % [95 % CI: -0.24, 0.12] (p = 0.5). Five of the nine studies, with a total of 112 subjects, comprised patients with diabetes mellitus (DM) type 2. The mean net change in HbA(1c) for the subjects with DM type 2 was 0.08 % [95 % CI: -0.26, 0.42] (p = 0.65). The mean net change in HbA(1c) for subjects with DM type 2 in studies that were at least 3 months in duration was 0.16 % [95 % CI: -0.26, 0.58] (p = 0.45). CONCLUSIONS: This meta-analysis found that CPAP does not reduce HbA(1c) levels when used in the short term.
Authors: Elizabeth Selvin; Michael W Steffes; Hong Zhu; Kunihiro Matsushita; Lynne Wagenknecht; James Pankow; Josef Coresh; Frederick L Brancati Journal: N Engl J Med Date: 2010-03-04 Impact factor: 91.245
Authors: Mora Murri; José Alcázar-Ramírez; Lourdes Garrido-Sánchez; Francisco Linde; Juan Alcaide; Fernando Cardona; Francisco J Tinahones Journal: Transl Res Date: 2009-06-27 Impact factor: 7.012
Authors: Patricia K Nguyen; Chandra K Katikireddy; Michael V McConnell; Clete Kushida; Phillip C Yang Journal: J Cardiovasc Magn Reson Date: 2010-09-03 Impact factor: 5.364
Authors: Igor Alexander Harsch; Simin Pour Schahin; Kerstin Brückner; Martin Radespiel-Tröger; Florian S Fuchs; Eckhart Georg Hahn; Peter Christopher Konturek; Tobias Lohmann; Joachim Hans Ficker Journal: Respiration Date: 2004 May-Jun Impact factor: 3.580
Authors: Arthur Dawson; Susan L Abel; Richard T Loving; George Dailey; Farhad F Shadan; John W Cronin; Daniel F Kripke; Lawrence E Kline Journal: J Clin Sleep Med Date: 2008-12-15 Impact factor: 4.062
Authors: Jamie Chung Mei Lam; Agnes Yuen Kwan Lai; Terence Chi Chun Tam; Michele Mae Ann Yuen; Karen Siu Ling Lam; Mary Sau Man Ip Journal: Sleep Breath Date: 2016-11-05 Impact factor: 2.816
Authors: Ivan Guerra de Araújo Freitas; Pedro Felipe Carvalhedo de Bruin; Lia Bittencourt; Veralice Meireles Sales de Bruin; Sérgio Tufik Journal: Sleep Breath Date: 2015-02-26 Impact factor: 2.816
Authors: James Patrick Smith; Luke G Cyr; Laura K Dowd; Kyla S Duchin; Priscilla A Lenihan; Jennifer Sprague Journal: Optom Vis Sci Date: 2019-11 Impact factor: 1.973
Authors: Louisa Schaller; Michael Arzt; Bettina Jung; Carsten A Böger; Iris M Heid; Stefan Stadler Journal: Front Neurol Date: 2021-12-02 Impact factor: 4.003