AIMS: It remains unclear as to whether regional atrial substrates of certain areas of the atrium in patients with atrial fibrillation (AF) can be related to sinoatrial node dysfunction. We investigated the relationship between the biatrial substrate characteristics and sinus node function in these patients. METHODS AND RESULTS: The study enrolled 34 patients (aged 57 ± 11 years old; 20 males) who underwent catheter ablation for symptomatic paroxysmal AF. Sinus node dysfunction was defined as having corrected sinus node recovery time longer than 550 ms. Atrial substrate analyses of both atria and atrial conductive properties were investigated in patients with (Group 1) and without sinus node dysfunction (Group 2). The mean global bipolar voltage of both atria and the atrial refractory period were similar between the two groups. Regional analysis showed that the mean bipolar voltage for patients in Group 1 was lower than in Group 2 (1.0 ± 0.3 vs. 2.1 ± 0.7 mV, P < 0.001) only in the sinus node region, while the electrophysiological properties were similar for both groups in other anatomic regions of both atria. The right atrial total activation time was significantly longer (97 ± 9 vs. 89 ± 10 ms, P = 0.023) and the conduction velocity along the crista terminalis was significantly slower (1.0 ± 0.2 vs. 1.2 ± 0.3 m/s, P = 0.019) in Group 1 patients than in Group 2 patients. CONCLUSION: In patients with AF, regional atrial remodelling near the sinus node area was associated with sinus node dysfunction.
AIMS: It remains unclear as to whether regional atrial substrates of certain areas of the atrium in patients with atrial fibrillation (AF) can be related to sinoatrial node dysfunction. We investigated the relationship between the biatrial substrate characteristics and sinus node function in these patients. METHODS AND RESULTS: The study enrolled 34 patients (aged 57 ± 11 years old; 20 males) who underwent catheter ablation for symptomatic paroxysmal AF. Sinus node dysfunction was defined as having corrected sinus node recovery time longer than 550 ms. Atrial substrate analyses of both atria and atrial conductive properties were investigated in patients with (Group 1) and without sinus node dysfunction (Group 2). The mean global bipolar voltage of both atria and the atrial refractory period were similar between the two groups. Regional analysis showed that the mean bipolar voltage for patients in Group 1 was lower than in Group 2 (1.0 ± 0.3 vs. 2.1 ± 0.7 mV, P < 0.001) only in the sinus node region, while the electrophysiological properties were similar for both groups in other anatomic regions of both atria. The right atrial total activation time was significantly longer (97 ± 9 vs. 89 ± 10 ms, P = 0.023) and the conduction velocity along the crista terminalis was significantly slower (1.0 ± 0.2 vs. 1.2 ± 0.3 m/s, P = 0.019) in Group 1 patients than in Group 2 patients. CONCLUSION: In patients with AF, regional atrial remodelling near the sinus node area was associated with sinus node dysfunction.
Authors: Jin Kyung Hwang; Hye Bin Gwag; Seung-Jung Park; Young Keun On; June Soo Kim; Kyoung-Min Park Journal: Clin Cardiol Date: 2018-04-17 Impact factor: 2.882
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Authors: Rosa B Thorolfsdottir; Gardar Sveinbjornsson; Hildur M Aegisdottir; Stefania Benonisdottir; Lilja Stefansdottir; Erna V Ivarsdottir; Gisli H Halldorsson; Jon K Sigurdsson; Christian Torp-Pedersen; Peter E Weeke; Søren Brunak; David Westergaard; Ole B Pedersen; Erik Sorensen; Kaspar R Nielsen; Kristoffer S Burgdorf; Karina Banasik; Ben Brumpton; Wei Zhou; Asmundur Oddsson; Vinicius Tragante; Kristjan E Hjorleifsson; Olafur B Davidsson; Sridharan Rajamani; Stefan Jonsson; Bjarni Torfason; Atli S Valgardsson; Gudmundur Thorgeirsson; Michael L Frigge; Gudmar Thorleifsson; Gudmundur L Norddahl; Anna Helgadottir; Solveig Gretarsdottir; Patrick Sulem; Ingileif Jonsdottir; Cristen J Willer; Kristian Hveem; Henning Bundgaard; Henrik Ullum; David O Arnar; Unnur Thorsteinsdottir; Daniel F Gudbjartsson; Hilma Holm; Kari Stefansson Journal: Eur Heart J Date: 2021-05-21 Impact factor: 29.983