| Literature DB >> 22770606 |
Selvaraj Jubie1, Patil Nilesh Ramesh, Palanichamy Dhanabal, Rajagopal Kalirajan, Nithyanantham Muruganantham, Anthoniswamy Shanish Antony.
Abstract
Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity.Entities:
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Year: 2012 PMID： 22770606 DOI： 10.1016/j.ejmech.2012.06.025
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514