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Literature DB >> 22768836

Replicative and chronological aging in Saccharomyces cerevisiae.

Valter D Longo¹, Gerald S Shadel, Matt Kaeberlein, Brian Kennedy.

Abstract

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model organism. Aging in yeast is assayed primarily by measurement of replicative or chronological life span. Here, we review the genes and mechanisms implicated in these two aging model systems and key remaining issues that need to be addressed for their optimization. Because of its well-characterized genome that is remarkably amenable to genetic manipulation and high-throughput screening procedures, S. cerevisiae will continue to serve as a leading model organism for studying pathways relevant to human aging and disease.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22768836 PMCID： PMC3392685 DOI： 10.1016/j.cmet.2012.06.002

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

134 in total

1. An intervention resembling caloric restriction prolongs life span and retards aging in yeast.

Authors: J C Jiang; E Jaruga; M V Repnevskaya; S M Jazwinski
Journal: FASEB J Date: 2000-11 Impact factor: 5.191

2. A stress-responsive system for mitochondrial protein degradation.

Authors: Jin-Mi Heo; Nurit Livnat-Levanon; Eric B Taylor; Kevin T Jones; Noah Dephoure; Julia Ring; Jianxin Xie; Jeffrey L Brodsky; Frank Madeo; Steven P Gygi; Kaveh Ashrafi; Michael H Glickman; Jared Rutter
Journal: Mol Cell Date: 2010-11-12 Impact factor: 17.970

Review 3. Sir2 and calorie restriction in yeast: a skeptical perspective.

Authors: Matt Kaeberlein; R Wilson Powers
Journal: Ageing Res Rev Date: 2007-04-19 Impact factor: 10.895

4. Life span extension and H(2)O(2) resistance elicited by caloric restriction require the peroxiredoxin Tsa1 in Saccharomyces cerevisiae.

Authors: Mikael Molin; Junsheng Yang; Sarah Hanzén; Michel B Toledano; Jean Labarre; Thomas Nyström
Journal: Mol Cell Date: 2011-09-02 Impact factor: 17.970

5. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

6. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis.

Authors: Hugo Aguilaniu; Lena Gustafsson; Michel Rigoulet; Thomas Nyström
Journal: Science Date: 2003-02-27 Impact factor: 47.728

7. Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast.

Authors: An M Aerts; Piotr Zabrocki; Gilmer Govaert; Janick Mathys; Didac Carmona-Gutierrez; Frank Madeo; Joris Winderickx; Bruno P A Cammue; Karin Thevissen
Journal: FEBS Lett Date: 2008-12-04 Impact factor: 4.124

8. Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae.

Authors: Nika Erjavec; Thomas Nyström
Journal: Proc Natl Acad Sci U S A Date: 2007-06-20 Impact factor: 11.205

9. The propeptide of yeast cathepsin D inhibits programmed necrosis.

Authors: D Carmona-Gutiérrez; M A Bauer; J Ring; H Knauer; T Eisenberg; S Büttner; C Ruckenstuhl; A Reisenbichler; C Magnes; G N Rechberger; R Birner-Gruenberger; H Jungwirth; K-U Fröhlich; F Sinner; G Kroemer; F Madeo
Journal: Cell Death Dis Date: 2011-05-19 Impact factor: 8.469

10. Inference of transcription modification in long-live yeast strains from their expression profiles.

Authors: Chao Cheng; Paola Fabrizio; Huanying Ge; Valter D Longo; Lei M Li
Journal: BMC Genomics Date: 2007-07-06 Impact factor: 3.969

265 in total

1. Preferential retrotransposition in aging yeast mother cells is correlated with increased genome instability.

Authors: Melissa N Patterson; Alison E Scannapieco; Pak Ho Au; Savanna Dorsey; Catherine A Royer; Patrick H Maxwell
Journal: DNA Repair (Amst) Date: 2015-08-07

Review 2. Protein and amino acid restriction, aging and disease: from yeast to humans.

Authors: Hamed Mirzaei; Jorge A Suarez; Valter D Longo
Journal: Trends Endocrinol Metab Date: 2014-08-19 Impact factor: 12.015

Review 3. Sphingolipids and lifespan regulation.

Authors: Xinhe Huang; Bradley R Withers; Robert C Dickson
Journal: Biochim Biophys Acta Date: 2013-08-15

4. Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.

Authors: Michelle T Burstein; Pavlo Kyryakov; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Anna Leonov; Sean Levy; Forough Noohi; Vladimir I Titorenko
Journal: Cell Cycle Date: 2012-08-16 Impact factor: 4.534

5. PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

Authors: Hong-Jing Cui; Xin-Guang Liu; Mark McCormick; Brian M Wasko; Wei Zhao; Xin He; Yuan Yuan; Bing-Xiong Fang; Xue-Rong Sun; Brian K Kennedy; Yousin Suh; Zhong-Jun Zhou; Matt Kaeberlein; Wen-Li Feng
Journal: Age (Dordr) Date: 2015-05-04

6. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.

Authors: Rita Vilaça; Elísio Silva; André Nadais; Vítor Teixeira; Nabil Matmati; Joana Gaifem; Yusuf A Hannun; Maria Clara Sá Miranda; Vítor Costa
Journal: Mol Microbiol Date: 2013-12-12 Impact factor: 3.501