Literature DB >> 22764769

Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment.

Claudia Palena1, Duane H Hamilton, Romaine I Fernando.   

Abstract

The phenomenon of epithelial-mesenchymal transition (EMT) has gained attention in the field of cancer biology for its potential contribution to the progression of carcinomas. Tumor EMT is a phenotypic switch that promotes the acquisition of a fibroblastoid-like morphology by epithelial tumor cells, resulting in enhanced tumor cell motility and invasiveness, increased metastatic propensity and resistance to chemotherapy, radiation and certain small-molecule-targeted therapies. Tumor cells undergoing EMT are also known to increase the secretion of specific factors, including cytokines, chemokines and growth factors, which could play an important role in tumor progression. This review summarizes the current knowledge on the secretory properties of epithelial tumor cells that have undergone an EMT, with an emphasis on the potential role of the IL-8-IL-8 receptor axis on the induction and/or maintenance of tumor EMT and its ability to remodel the tumor microenvironment.

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Year:  2012        PMID： 22764769      PMCID： PMC3462442          DOI： 10.2217/fon.12.59

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  80 in total

1.  Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells.

Authors:  Sara A Illman; Kaisa Lehti; Jorma Keski-Oja; Jouko Lohi
Journal:  J Cell Sci       Date:  2006-08-29       Impact factor: 5.285

2.  Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.

Authors:  Yelena Mironchik; Paul T Winnard; Farhad Vesuna; Yoshinori Kato; Flonne Wildes; Arvind P Pathak; Scott Kominsky; Dmitri Artemov; Zaver Bhujwalla; Paul Van Diest; Horst Burger; Carlotta Glackin; Venu Raman
Journal:  Cancer Res       Date:  2005-12-01       Impact factor: 12.701

Review 3.  Complex networks orchestrate epithelial-mesenchymal transitions.

Authors:  Jean Paul Thiery; Jonathan P Sleeman
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

4.  Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma.

Authors:  Jin-Yuan Shih; Meng-Feng Tsai; Tzu-Hua Chang; Yih-Leong Chang; Ang Yuan; Chong-Jen Yu; Shin-Bey Lin; Geou-Yarh Liou; Meng-Larn Lee; Jeremy J W Chen; Tse-Ming Hong; Shuenn-Chen Yang; Jen-Liang Su; Yung-Chie Lee; Pan-Chyr Yang
Journal:  Clin Cancer Res       Date:  2005-11-15       Impact factor: 12.531

5.  Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2.

Authors:  Christine L Chaffer; Janelle P Brennan; John L Slavin; Tony Blick; Erik W Thompson; Elizabeth D Williams
Journal:  Cancer Res       Date:  2006-12-01       Impact factor: 12.701

Review 6.  Cysteine cathepsins: multifunctional enzymes in cancer.

Authors:  Mona Mostafa Mohamed; Bonnie F Sloane
Journal:  Nat Rev Cancer       Date:  2006-10       Impact factor: 60.716

7.  K-ras activation generates an inflammatory response in lung tumors.

Authors:  H Ji; A M Houghton; T J Mariani; S Perera; C B Kim; R Padera; G Tonon; K McNamara; L A Marconcini; A Hezel; N El-Bardeesy; R T Bronson; D Sugarbaker; R S Maser; S D Shapiro; K-K Wong
Journal:  Oncogene       Date:  2006-03-30       Impact factor: 9.867

8.  The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy.

Authors:  Claudia Palena; Dmitry E Polev; Kwong Y Tsang; Romaine I Fernando; Mary Litzinger; Larisa L Krukovskaya; Ancha V Baranova; Andrei P Kozlov; Jeffrey Schlom
Journal:  Clin Cancer Res       Date:  2007-04-15       Impact factor: 12.531

9.  Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition.

Authors:  Stuart Thomson; Elizabeth Buck; Filippo Petti; Graeme Griffin; Eric Brown; Nishal Ramnarine; Kenneth K Iwata; Neil Gibson; John D Haley
Journal:  Cancer Res       Date:  2005-10-15       Impact factor: 12.701

Review 10.  The IL-6/sIL-6R complex as a novel target for therapeutic approaches.

Authors:  Stefan Rose-John; Georg H Waetzig; Jürgen Scheller; Joachim Grötzinger; Dirk Seegert
Journal:  Expert Opin Ther Targets       Date:  2007-05       Impact factor: 6.902
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  77 in total

1.  Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-κB-Snail signaling in glioma.

Authors:  Baogang Zhang; Lihong Shi; Shijun Lu; Xiuning Sun; Yuqing Liu; Hongli Li; Xuejian Wang; Chunzhen Zhao; Heng Zhang; Ying Wang
Journal:  Cancer Biol Ther       Date:  2015-04-14       Impact factor: 4.742

2.  Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells.

Authors:  Xiaojia Chen; Jia Lu; Yuhua Ji; An Hong; Qiuling Xie
Journal:  Tumour Biol       Date:  2013-09-12

3.  Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway.

Authors:  C Visciano; F Liotti; N Prevete; G Cali'; R Franco; F Collina; A de Paulis; G Marone; M Santoro; R M Melillo
Journal:  Oncogene       Date:  2015-01-26       Impact factor: 9.867

4.  Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.

Authors:  Cristina Vanni; Marzia Ognibene; Federica Finetti; Patrizia Mancini; Sara Cabodi; Daniela Segalerba; Maria Rosaria Torrisi; Sandra Donnini; Maria Carla Bosco; Luigi Varesio; Alessandra Eva
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

5.  IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling.

Authors:  Nan Zhou; Fuding Lu; Cheng Liu; Kewei Xu; Jian Huang; Dexin Yu; Liangkuan Bi
Journal:  Oncol Lett       Date:  2016-07-21       Impact factor: 2.967

6.  Brachyury, a vaccine target, is overexpressed in triple-negative breast cancer.

Authors:  Duane H Hamilton; Mario Roselli; Claudia Palena; Fiorella Guadagni; Patrizia Ferroni; Leopoldo Costarelli; Francesco Cavaliere; Mariateresa Taffuri
Journal:  Endocr Relat Cancer       Date:  2016-10       Impact factor: 5.678

Review 7.  Epithelial-mesenchymal transition and inflammation at the site of the primary tumor.

Authors:  Charli Dominguez; Justin M David; Claudia Palena
Journal:  Semin Cancer Biol       Date:  2017-08-18       Impact factor: 15.707

8.  IL-8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells.

Authors:  Linlin Jia; Fengying Li; Mingliang Shao; Wei Zhang; Chunbin Zhang; Xiaolian Zhao; Haiyan Luan; Yaling Qi; Pengxia Zhang; Lichun Liang; Xiuyue Jia; Kun Zhang; Yan Lu; Zhe Yang; Xiulin Zhu; Qi Zhang; Jiwei Du; Weiqun Wang
Journal:  Oncol Lett       Date:  2017-11-10       Impact factor: 2.967

9.  The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression.

Authors:  Limo Chen; John V Heymach; F Xiao-Feng Qin; Don L Gibbons
Journal:  Oncoimmunology       Date:  2015-02-03       Impact factor: 8.110

10.  CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

Authors:  Mengqian Chen; Jiaxin Liang; Hao Ji; Zhengguan Yang; Serena Altilia; Bing Hu; Adam Schronce; Martina S J McDermott; Gary P Schools; Chang-Uk Lim; David Oliver; Michael S Shtutman; Tao Lu; George R Stark; Donald C Porter; Eugenia V Broude; Igor B Roninson
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-30       Impact factor: 11.205
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