BACKGROUND: African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to have suboptimal concentrations of circulating 25-hydroxyvitamin D [25(OH)D]. The results of epidemiologic and observational studies suggest that there is a link between vitamin D deficiency and the risk of cardiometabolic disorders, which underscores the importance of maintaining healthy concentrations of 25(OH)D. OBJECTIVE: The objective was to investigate whether daily supplementation with 4000 IU vitamin D(3) for 1 y would eliminate any disparities in circulating concentrations of 25(OH)D between African American and white men. DESIGN: Serum concentrations of 25(OH)D were measured every 2 mo in 47 subjects who received a daily oral dose of 4000 IU vitamin D(3) for 1 y. RESULTS: More than 90% of African Americans had serum concentrations of 25(OH)D <32 ng/mL, and approximately two-thirds had serum concentrations <20 ng/mL. Furthermore, there were significant disparities in serum concentrations of 25(OH)D between African American and white men. Supplementation with 4000 IU/d for 1 y eliminated any significant differences in circulating concentrations of 25(OH)D between African American and white men. CONCLUSION: The results of this clinical study show the feasibility and efficacy of this approach in the elimination of hypovitaminosis D, which is a widespread health disparity among African Americans. This trial was registered at clinicaltrials.gov as NCT01045109.
BACKGROUND: African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to have suboptimal concentrations of circulating 25-hydroxyvitamin D [25(OH)D]. The results of epidemiologic and observational studies suggest that there is a link between vitamin D deficiency and the risk of cardiometabolic disorders, which underscores the importance of maintaining healthy concentrations of 25(OH)D. OBJECTIVE: The objective was to investigate whether daily supplementation with 4000 IU vitamin D(3) for 1 y would eliminate any disparities in circulating concentrations of 25(OH)D between African American and white men. DESIGN: Serum concentrations of 25(OH)D were measured every 2 mo in 47 subjects who received a daily oral dose of 4000 IU vitamin D(3) for 1 y. RESULTS: More than 90% of African Americans had serum concentrations of 25(OH)D <32 ng/mL, and approximately two-thirds had serum concentrations <20 ng/mL. Furthermore, there were significant disparities in serum concentrations of 25(OH)D between African American and white men. Supplementation with 4000 IU/d for 1 y eliminated any significant differences in circulating concentrations of 25(OH)D between African American and white men. CONCLUSION: The results of this clinical study show the feasibility and efficacy of this approach in the elimination of hypovitaminosis D, which is a widespread health disparity among African Americans. This trial was registered at clinicaltrials.gov as NCT01045109.
Authors: Gary Hardiman; Stephen J Savage; E Starr Hazard; Robert C Wilson; Sean M Courtney; Michael T Smith; Bruce W Hollis; Chanita Hughes Halbert; Sebastiano Gattoni-Celli Journal: Pharmacogenomics Date: 2016-06-30 Impact factor: 2.533
Authors: Sushil K Jain; Prasenjit Manna; David Micinski; Benjamin J Lieblong; Gunjan Kahlon; Lester Morehead; Robert Hoeldtke; Pat Farrington Bass; Steven N Levine Journal: Antioxid Redox Signal Date: 2012-09-13 Impact factor: 8.401
Authors: Patrick J McCullough; William P McCullough; Douglas Lehrer; Jeffrey B Travers; Steven J Repas Journal: Nutrients Date: 2021-04-29 Impact factor: 5.717
Authors: Sushil K Jain; Gunjan Kahlon; Pat Bass; Steven N Levine; Cassandra Warden Journal: Antioxid Redox Signal Date: 2015-05-29 Impact factor: 8.401
Authors: Ken Batai; Adam B Murphy; Ebony Shah; Maria Ruden; Jennifer Newsome; Sara Agate; Michael A Dixon; Hua Yun Chen; Leslie A Deane; Courtney M P Hollowell; Chiledum Ahaghotu; Rick A Kittles Journal: Hum Genet Date: 2014-08-02 Impact factor: 4.132