Literature DB >> 27359067

Systems analysis of the prostate transcriptome in African-American men compared with European-American men.

Gary Hardiman1,2, Stephen J Savage3,4, E Starr Hazard2,5, Robert C Wilson2,6, Sean M Courtney2, Michael T Smith6, Bruce W Hollis7, Chanita Hughes Halbert4,8, Sebastiano Gattoni-Celli4,9.   

Abstract

AIM: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D3 supplementation. PATIENTS &
METHODS: Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D3 (4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery.
RESULTS: AA show higher expression of genes associated with immune response and inflammation.
CONCLUSION: Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D3 supplementation.

Entities:  

Keywords:  African–American; RNA-seq; health disparities; prostate; transcription; vitamin D

Mesh：

Substances：

Year:  2016        PMID： 27359067      PMCID： PMC6040053          DOI： 10.2217/pgs-2016-0025

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  43 in total

1.  Vitamin D3 from rat skins irradiated in vitro with ultraviolet light.

Authors:  R P Esvelt; H K Schnoes; H F DeLuca
Journal:  Arch Biochem Biophys       Date:  1978-06       Impact factor: 4.013

2.  Clinical characteristics in black and white men with prostate cancer in an equal access medical center.

Authors:  S J Freedland; M E Sutter; J Naitoh; F Dorey; G S Csathy; W J Aronson
Journal:  Urology       Date:  2000-03       Impact factor: 2.649

Review 3.  Vitamin D3 supplementation, low-risk prostate cancer, and health disparities.

Authors:  Bruce W Hollis; David T Marshall; Stephen J Savage; Elizabeth Garrett-Mayer; Mark S Kindy; Sebastiano Gattoni-Celli
Journal:  J Steroid Biochem Mol Biol       Date:  2012-12-07       Impact factor: 4.292

4.  Regulation of human vitamin D(3) 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells.

Authors:  Maria Ellfolk; Maria Norlin; Katarina Gyllensten; Kjell Wikvall
Journal:  Mol Pharmacol       Date:  2009-03-13       Impact factor: 4.436

5.  Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3.

Authors:  G G Schwartz; L W Whitlatch; T C Chen; B L Lokeshwar; M F Holick
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  1998-05       Impact factor: 4.254

6.  Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994.

Authors:  Shanna Nesby-O'Dell; Kelley S Scanlon; Mary E Cogswell; Cathleen Gillespie; Bruce W Hollis; Anne C Looker; Chris Allen; Cindy Doughertly; Elaine W Gunter; Barbara A Bowman
Journal:  Am J Clin Nutr       Date:  2002-07       Impact factor: 7.045

7.  Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence.

Authors:  Brian L Cohen; Pablo Gomez; Yohei Omori; Robert C Duncan; Francisco Civantos; Mark S Soloway; Vinata B Lokeshwar; Bal L Lokeshwar
Journal:  Int J Cancer       Date:  2006-09-01       Impact factor: 7.396

8.  Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.

Authors:  Anne C Looker; Christine M Pfeiffer; David A Lacher; Rosemary L Schleicher; Mary Frances Picciano; Elizabeth A Yetley
Journal:  Am J Clin Nutr       Date:  2008-12       Impact factor: 7.045

9.  Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial.

Authors:  Paulette D Chandler; Edward L Giovannucci; Jamil B Scott; Gary G Bennett; Kimmie Ng; Andrew T Chan; Bruce W Hollis; Karen M Emmons; Charles S Fuchs; Bettina F Drake
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2014-06-28       Impact factor: 4.254

10.  A degenerative retinal process in HIV-associated non-infectious retinopathy.

Authors:  Igor Kozak; Roman Sasik; William R Freeman; L James Sprague; Maria Laura Gomez; Lingyun Cheng; Sharif El-Emam; Francesca Mojana; Dirk-Uwe Bartsch; Jenny Bosten; Radha Ayyagari; Gary Hardiman
Journal:  PLoS One       Date:  2013-09-17       Impact factor: 3.240
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  35 in total

Review 1.  Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer.

Authors:  LaCreis R Kidd; K Sean Kimbro; Susan T Yeyeodu
Journal:  Cancer Immunol Res       Date:  2019-09       Impact factor: 11.151

Review 2.  Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans.

Authors:  Jacqueline Olender; Norman H Lee
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

3.  Prostatic compensation of the vitamin D axis in African American men.

Authors:  Zachary Richards; Ken Batai; Rachael Farhat; Ebony Shah; Andrew Makowski; Peter H Gann; Rick Kittles; Larisa Nonn
Journal:  JCI Insight       Date:  2017-01-26

Review 4.  Analysis of Tumor Biology to Advance Cancer Health Disparity Research.

Authors:  Cheryl J Smith; Tsion Z Minas; Stefan Ambs
Journal:  Am J Pathol       Date:  2017-11-11       Impact factor: 4.307

5.  Aspirin Use Reduces the Risk of Aggressive Prostate Cancer and Disease Recurrence in African-American Men.

Authors:  Cheryl Jacobs Smith; Tiffany H Dorsey; Wei Tang; Symone V Jordan; Christopher A Loffredo; Stefan Ambs
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-03-14       Impact factor: 4.254

6.  MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer.

Authors:  Renée de Leeuw; Christopher McNair; Matthew J Schiewer; Neermala Poudel Neupane; Lucas J Brand; Michael A Augello; Zhen Li; Larry C Cheng; Akihiro Yoshida; Sean M Courtney; E Starr Hazard; Gary Hardiman; Maha H Hussain; J Alan Diehl; Justin M Drake; Wm Kevin Kelly; Karen E Knudsen
Journal:  Clin Cancer Res       Date:  2018-05-08       Impact factor: 12.531

7.  Vitamin D supplementation decreases immune activation and exhaustion in HIV-1-infected youth.

Authors:  Allison Ross Eckard; Mary Ann O'Riordan; Julia C Rosebush; Seungeun Thera Lee; Jakob G Habib; Joshua H Ruff; Danielle Labbato; Julie E Daniels; Monika Uribe-Leitz; Vin Tangpricha; Ann Chahroudi; Grace A McComsey
Journal:  Antivir Ther       Date:  2018

8.  IFNL4-ΔG Allele Is Associated with an Interferon Signature in Tumors and Survival of African-American Men with Prostate Cancer.

Authors:  Wei Tang; Tiffany A Wallace; Ming Yi; Cristina Magi-Galluzzi; Tiffany H Dorsey; Olusegun O Onabajo; Adeola Obajemu; Symone V Jordan; Christopher A Loffredo; Robert M Stephens; Robert H Silverman; George R Stark; Eric A Klein; Ludmila Prokunina-Olsson; Stefan Ambs
Journal:  Clin Cancer Res       Date:  2018-07-16       Impact factor: 12.531

9.  Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans.

Authors:  Khadijah A Mitchell; Adriana Zingone; Leila Toulabi; Jacob Boeckelman; Bríd M Ryan
Journal:  Clin Cancer Res       Date:  2017-12-01       Impact factor: 12.531

10.  Influence of vitamin D on cancer risk and treatment: Why the variability?

Authors:  M Rita I Young; Ying Xiong
Journal:  Trends Cancer Res       Date:  2018
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