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Literature DB >> 22752944

False positive cardiac troponin elevation due to heterophile antibodies: more common than we recognise?

Abstract

A 53-year-old woman was admitted with non-exertional chest pain and elevated cardiac troponin I (cTnI) without dynamic changes of ischaemia on the ECG. She had recently undergone coronary angiography which had shown normal coronary vessels. Repeat angiography on this admission was again unremarkable. Samples of blood were sent for analysis using different troponin assays and demonstrated chronic basal elevation of cTnI while simultaneous assay for troponin T (cTnT) remained normal. Subsequent testing revealed the presence of heterophile antibodies interfering with the troponin I assay leading to a false positive result.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 22752944 PMCID： PMC3034207 DOI： 10.1136/bcr.11.2009.2477

Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X

14 in total

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5 in total

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Authors: Guy Lefort; Claude D'Antonio; Terrell Caffery
Journal: BMJ Case Rep Date: 2014-04-04

2. Ultra-high sensitivity cardiac troponin-I concentration and left ventricular structure and function in women with ischemia and no obstructive coronary artery disease.

Authors: Odayme Quesada; Omeed Elboudwarej; Michael D Nelson; Ahmed Al-Badri; Mitra Mastali; Janet Wei; Bijan Zarrabi; Nissi Suppogu; Haider Aldiwani; Puja Mehta; Chrisandra Shufelt; Galen Cook-Wiens; Daniel S Berman; Louise E J Thomson; Eileen Handberg; Carl J Pepine; Jennifer E Van Eyk; C Noel Bairey Merz
Journal: Am Heart J Plus Date: 2022-03-03