Literature DB >> 227529

The influence of naloxone on the C fiber response of dorsal horn neurons and their inhibitory control by raphe magnus stimulation.

J P Rivot, A Chaouch, J M Besson.   

Abstract

In intact rats anesthetized with chloralose, the effects of naloxone were studied on the responses of spinal cord dorsal horn neurons to C fiber stimulation and upon the inhibition induced on these responses by stimulation of the nucleus raphé magnus (NRM). (1) A mean 44% facilitatory effect on responses to C fibers was observed for 12/19 units. (2) A mean 30% reduction of the inhibitory effects of NRM was found for 14/29 units. (3) However there is no clear relationship between these facilitatory effects and the diminution of the efficiency of NRM stimulation. These results demonstrate a facilitatory effect of naloxone upon the transmission of noxious messages at the spinal level and confirm that opiate endogenous substances are implicated in the inhibitory mechanisms activated by stimulation of NRM.

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Year:  1979        PMID： 227529     DOI： 10.1016/0006-8993(79)90989-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  N-methyl-D-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce mu-opioid receptor internalization in the rat spinal cord.

Authors:  B Song; J C G Marvizón
Journal:  Neuroscience       Date:  2005-10-03       Impact factor: 3.590

2.  Effects of aspirin, naloxone and placebo.

Authors:  A A Mewa; D Rosenbloom; E M Grace; P Brooks; N Bellamy; C Denko; G Norman; W W Buchanan
Journal:  Clin Rheumatol       Date:  1987-12       Impact factor: 2.980

Review 3.  Supraspinal morphine and descending inhibitions acting on the dorsal horn of the rat.

Authors:  A H Dickenson; D Le Bars
Journal:  J Physiol       Date:  1987-03       Impact factor: 5.182

Review 4.  Endogenous opioids and pain: a review.

Authors:  R G Hill
Journal:  J R Soc Med       Date:  1981-06       Impact factor: 5.344

5.  Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos.

Authors:  Dusica Bajic; Kathryn G Commons
Journal:  Brain Res       Date:  2009-10-13       Impact factor: 3.252

6.  The effect of naloxone on spinal reflexes to electrical and mechanical stimuli in the anaesthetized, spinalized rat.

Authors:  N A Hartell; P M Headley
Journal:  J Physiol       Date:  1991-10       Impact factor: 5.182

7.  Effects of intrathecally administered pentobarbital and naloxone on the activity evoked in ascending axons of the rat spinal cord by stimulation of afferent A and C fibres. Further evidence for a tonic endorphinergic inhibition in nociception.

Authors:  G Bernatzky; T Doi; I Jurna
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-07       Impact factor: 3.000

8.  Intrathecal substance P depresses spinal motor and sensory responses to stimulation of nociceptive afferents--antagonism by naloxone.

Authors:  T Doi; I Jurna
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-05       Impact factor: 3.000
  8 in total

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