BACKGROUND AND OBJECTIVES: We assessed the ability of positron emission tomography-computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancer patients. METHODS: A total of 239 gastric cancer patients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake. The PET/CT findings were compared with the results of concurrent colonoscopy. RESULTS: In group A, a total of 123 polyps of >0 mm were observed. Of these, nine polyps were colonic adenocarcinomas and six were high-grade dysplasia. The incidence of colonic adenocarcinomas was significantly higher in group A than in the other two groups (p = 0.037). There was a significant correlation between SUVmax values and incidence of colonic polyps of >10 mm (r = 0.471, p = 0.04). The distribution pattern of SUVmax in polyps with adenoma (>10 mm) was less homogenous than in polyps (>10 mm) with adenocarcinoma. CONCLUSIONS: The focal colonic FDG uptake in PET/CT requires colonoscopic confirmation. The suspicion of colonic malignancy increased in the presence of polyps >10 mm that showed a positive correlation with the SUVmax.
BACKGROUND AND OBJECTIVES: We assessed the ability of positron emission tomography-computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancerpatients. METHODS: A total of 239 gastric cancerpatients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake. The PET/CT findings were compared with the results of concurrent colonoscopy. RESULTS: In group A, a total of 123 polyps of >0 mm were observed. Of these, nine polyps were colonic adenocarcinomas and six were high-grade dysplasia. The incidence of colonic adenocarcinomas was significantly higher in group A than in the other two groups (p = 0.037). There was a significant correlation between SUVmax values and incidence of colonic polyps of >10 mm (r = 0.471, p = 0.04). The distribution pattern of SUVmax in polyps with adenoma (>10 mm) was less homogenous than in polyps (>10 mm) with adenocarcinoma. CONCLUSIONS: The focal colonic FDG uptake in PET/CT requires colonoscopic confirmation. The suspicion of colonic malignancy increased in the presence of polyps >10 mm that showed a positive correlation with the SUVmax.
Authors: Brian R Weston; Revathy B Iyer; Wei Qiao; Jeffrey H Lee; Robert S Bresalier; William A Ross Journal: Cancer Date: 2010-03-15 Impact factor: 6.860
Authors: Mariëtte C A van Kouwen; Fokko M Nagengast; Jan B M J Jansen; Wim J G Oyen; Joost P H Drenth Journal: J Clin Oncol Date: 2005-06-01 Impact factor: 44.544
Authors: Seok-Ki Kim; Keon Wook Kang; Jong Seok Lee; Hark Kyun Kim; Hee Jin Chang; Jin Yi Choi; Jun Ho Lee; Keun Won Ryu; Young-Woo Kim; Jae-Moon Bae Journal: Eur J Nucl Med Mol Imaging Date: 2005-10-15 Impact factor: 9.236
Authors: Julian Kirchner; Benedikt M Schaarschmidt; Firas Kour; Lino M Sawicki; Ole Martin; Johannes Bode; Stephan Vom Dahl; Verena Keitel; Dieter Häussinger; Christina Antke; Christian Buchbender; Gerald Antoch; Philipp Heusch Journal: Eur J Nucl Med Mol Imaging Date: 2019-11-07 Impact factor: 9.236