BACKGROUND: The ability of integrated positron emission tomography and computed axial tomography (PET-CT) to detect colonic pathology is not fully defined. The purpose of this study was to assess the ability of PET-CT to detect colonic pathology and to determine the significance of ((18)F)2-fluoro-2-deoxyglucose ((18)F-FDG) activity noted incidentally in the colon on PET-CT. METHODS: Records for all patients who underwent PET-CT and colonoscopy at our institution were reviewed. Patients with history of colonic malignancy or colon surgery were excluded. RESULTS: Fifty-eight patients had incidental colonic (18)F-FDG activity on PET (Group A) and 272 had none (Group B). In Group A, 65% of patients had pathologic findings detected on colonoscopy that corresponded to the site of PET activity. Standardized uptake value (SUV) readings were not helpful in distinguishing true-positives from false-positives. In Group B, 11.8% of patients were found to have significant colonic findings. Lesions not detected by PET-CT included 4 colon cancers, 7 advanced adenomas, and 10 patients with colonic lymphoma. Overall, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT for detecting significant pathology were 53%, 93%, 65%, 89%, and 85%, respectively. For detecting colon cancer and adenomas 10 mm or more, the sensitivity, specificity, PPV, NPV, and accuracy of PET-CT were 72%, 90%, 45%, 96%, and 88%, respectively. CONCLUSIONS: Incidental colonic activity detected by PET-CT warrants further evaluation with colonoscopy. However, negative PET-CT does not rule out significant colonic pathology including colon cancer, advanced adenomas, or lymphoma.
BACKGROUND: The ability of integrated positron emission tomography and computed axial tomography (PET-CT) to detect colonic pathology is not fully defined. The purpose of this study was to assess the ability of PET-CT to detect colonic pathology and to determine the significance of ((18)F)2-fluoro-2-deoxyglucose ((18)F-FDG) activity noted incidentally in the colon on PET-CT. METHODS: Records for all patients who underwent PET-CT and colonoscopy at our institution were reviewed. Patients with history of colonic malignancy or colon surgery were excluded. RESULTS: Fifty-eight patients had incidental colonic (18)F-FDG activity on PET (Group A) and 272 had none (Group B). In Group A, 65% of patients had pathologic findings detected on colonoscopy that corresponded to the site of PET activity. Standardized uptake value (SUV) readings were not helpful in distinguishing true-positives from false-positives. In Group B, 11.8% of patients were found to have significant colonic findings. Lesions not detected by PET-CT included 4 colon cancers, 7 advanced adenomas, and 10 patients with colonic lymphoma. Overall, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT for detecting significant pathology were 53%, 93%, 65%, 89%, and 85%, respectively. For detecting colon cancer and adenomas 10 mm or more, the sensitivity, specificity, PPV, NPV, and accuracy of PET-CT were 72%, 90%, 45%, 96%, and 88%, respectively. CONCLUSIONS: Incidental colonic activity detected by PET-CT warrants further evaluation with colonoscopy. However, negative PET-CT does not rule out significant colonic pathology including colon cancer, advanced adenomas, or lymphoma.
Authors: Richdeep S Gill; Troy Perry; Jonathan T Abele; Eric L R Bédard; Daniel Schiller Journal: World J Surg Oncol Date: 2012-01-27 Impact factor: 2.754
Authors: Julian Kirchner; Benedikt M Schaarschmidt; Firas Kour; Lino M Sawicki; Ole Martin; Johannes Bode; Stephan Vom Dahl; Verena Keitel; Dieter Häussinger; Christina Antke; Christian Buchbender; Gerald Antoch; Philipp Heusch Journal: Eur J Nucl Med Mol Imaging Date: 2019-11-07 Impact factor: 9.236
Authors: Jung Ho Shim; Joo Hyun O; Seong Il Oh; Han Mo Yoo; Hae Myung Jeon; Cho Hyun Park; Sung Hoon Kim; Kyo Young Song Journal: J Gastrointest Surg Date: 2012-06-30 Impact factor: 3.452
Authors: Cornelia Bettina Brendle; Philip Aschoff; Thomas Kratt; Christina Schraml; Matthias Reimold; Claus Detlef Claussen; Christina Anna Pfannenberg Journal: Korean J Radiol Date: 2013-11-05 Impact factor: 3.500