Literature DB >> 22750790

H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine.

Piroska E Szabó1, Gerd P Pfeifer.   

Abstract

Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus. Recent work has shown that the maternal genome is protected from this remodeling step by an interaction between a modified histone, H3K9me2, and the oocyte-derived factor, PGC7, to prevent oxidation of the maternal DNA by the Tet3 5-methylcytosine oxidase.

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Year:  2012        PMID： 22750790     DOI： 10.1093/jmcb/mjs038

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  7 in total

Review 1.  5-Hydroxymethylcytosine: a stable or transient DNA modification?

Authors:  Maria A Hahn; Piroska E Szabó; Gerd P Pfeifer
Journal:  Genomics       Date:  2014-08-30       Impact factor: 5.736

2.  Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells.

Authors:  Yongyan Wu; Zekun Guo; Ye Liu; Bo Tang; Yi Wang; Liping Yang; Juan Du; Yong Zhang
Journal:  Mol Biol Rep       Date:  2012-12-20       Impact factor: 2.316

Review 3.  Playing TETris with DNA modifications.

Authors:  Benjamin Delatte; Rachel Deplus; François Fuks
Journal:  EMBO J       Date:  2014-05-13       Impact factor: 11.598

Review 4.  Understanding the relationship between DNA methylation and histone lysine methylation.

Authors:  Nathan R Rose; Robert J Klose
Journal:  Biochim Biophys Acta       Date:  2014-02-19

5.  Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI.

Authors:  Sonia Heras; Katrien Smits; Catharina De Schauwer; Ann Van Soom
Journal:  Epigenetics Chromatin       Date:  2017-03-15       Impact factor: 4.954

Review 6.  Is imprinting the result of "friendly fire" by the host defense system?

Authors:  Miroslava Ondičová; Rebecca J Oakey; Colum P Walsh
Journal:  PLoS Genet       Date:  2020-04-09       Impact factor: 5.917

7.  5-hydroxymethylcytosine and its potential roles in development and cancer.

Authors:  Gerd P Pfeifer; Swati Kadam; Seung-Gi Jin
Journal:  Epigenetics Chromatin       Date:  2013-05-01       Impact factor: 4.954
  7 in total

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