OBJECTIVES: To prospectively assess dynamic contrast-enhanced (DCE-)MRI as compared to conventional sequences in patients with luminal Crohn's disease. METHODS: Patients with Crohn's disease undergoing MRI and ileocolonoscopy within 1 month had DCE-MRI (3T) during intravenous contrast injection of gadobutrol, single shot fast spin echo sequence and 3D T1-weighted spoiled gradient echo sequence, a dynamic coronal 3D T1-weighted fast spoiled gradient were performed before and after gadobutrol. Maximum enhancement (ME) and initial slope of increase (ISI) were calculated for four colon segments (ascending colon+coecum, transverse colon, descending colon+sigmoid, rectum) and (neo)terminal ileum. C-reactive protein (CRP), Crohn's disease activity index (CDAI), per patient and per segment Crohn's disease endoscopic index of severity (CDEIS) and disease duration were determined. Mean values of the (DCE-)MRI parameters in each segment from each patient were compared between four disease activity groups (normal mucosa, non-ulcerative lesions, mild ulcerative and severe ulcerative disease) with Mann-Whitney test with Bonferroni adjustment. Spearman correlation coefficients were calculated for continuous variables. RESULTS: Thirty-three patients were included (mean age 37 years; 23 females, median CDEIS 4.4). ME and ISI correlated weakly with segmental CDEIS (r=0.485 and r=0.206) and ME per patient correlated moderately with CDEIS (r=0.551). ME was significantly higher in segments with mild (0.378) or severe (0.388) ulcerative disease compared to normal mucosa (0.304) (p<0.001). No ulcerations were identified at conventional sequences. ME correlated with disease duration in diseased segments (r=0.492), not with CDAI and CRP. CONCLUSIONS: DCE-MRI can be used as a method for detecting Crohn's disease ulcerative lesions.
OBJECTIVES: To prospectively assess dynamic contrast-enhanced (DCE-)MRI as compared to conventional sequences in patients with luminal Crohn's disease. METHODS:Patients with Crohn's disease undergoing MRI and ileocolonoscopy within 1 month had DCE-MRI (3T) during intravenous contrast injection of gadobutrol, single shot fast spin echo sequence and 3D T1-weighted spoiled gradient echo sequence, a dynamic coronal 3D T1-weighted fast spoiled gradient were performed before and after gadobutrol. Maximum enhancement (ME) and initial slope of increase (ISI) were calculated for four colon segments (ascending colon+coecum, transverse colon, descending colon+sigmoid, rectum) and (neo)terminal ileum. C-reactive protein (CRP), Crohn's disease activity index (CDAI), per patient and per segment Crohn's disease endoscopic index of severity (CDEIS) and disease duration were determined. Mean values of the (DCE-)MRI parameters in each segment from each patient were compared between four disease activity groups (normal mucosa, non-ulcerative lesions, mild ulcerative and severe ulcerative disease) with Mann-Whitney test with Bonferroni adjustment. Spearman correlation coefficients were calculated for continuous variables. RESULTS: Thirty-three patients were included (mean age 37 years; 23 females, median CDEIS 4.4). ME and ISI correlated weakly with segmental CDEIS (r=0.485 and r=0.206) and ME per patient correlated moderately with CDEIS (r=0.551). ME was significantly higher in segments with mild (0.378) or severe (0.388) ulcerative disease compared to normal mucosa (0.304) (p<0.001). No ulcerations were identified at conventional sequences. ME correlated with disease duration in diseased segments (r=0.492), not with CDAI and CRP. CONCLUSIONS:DCE-MRI can be used as a method for detecting Crohn's disease ulcerative lesions.
Authors: Robiel E Naziroglu; Carl A J Puylaert; Jeroen A W Tielbeek; Jesica Makanyanga; Alex Menys; Cyriel Y Ponsioen; Haralambos Hatzakis; Stuart A Taylor; Jaap Stoker; Lucas J van Vliet; Frans M Vos Journal: Br J Radiol Date: 2017-05-23 Impact factor: 3.039
Authors: Manon L W Ziech; Thalia Z Hummel; Anne M J B Smets; Rutger A J Nievelstein; Cristina Lavini; Matthan W A Caan; Aart J Nederveen; Joris J T H Roelofs; Shandra Bipat; Marc A Benninga; Angelika Kindermann; Jaap Stoker Journal: Pediatr Radiol Date: 2014-06-06
Authors: Bartłomiej W Papież; James M Franklin; Mattias P Heinrich; Fergus V Gleeson; Michael Brady; Julia A Schnabel Journal: J Med Imaging (Bellingham) Date: 2018-04-04
Authors: Reena Khanna; Sigrid A Nelson; Brian G Feagan; Geert D'Haens; William J Sandborn; G Y Zou; John K MacDonald; Claire E Parker; Vipul Jairath; Barrett G Levesque Journal: Cochrane Database Syst Rev Date: 2016-08-08
Authors: Jeroen A W Tielbeek; Manon L W Ziech; Zhang Li; Cristina Lavini; Shandra Bipat; Willem A Bemelman; Joris J T H Roelofs; Cyriel Y Ponsioen; Frans M Vos; Jaap Stoker Journal: Eur Radiol Date: 2013-09-15 Impact factor: 5.315