Literature DB >> 22743150

Pancreatic adenocarcinoma presenting with sudden onset bilateral deafness secondary to metastatic leptomeningeal infiltration.

Samuel Joseph Blows1, Richard Morgan, Umeet Dhariwal, Gemma Petts, Frederico Roncaroli.   

Abstract

Deafness is a very common problem in older persons. We present a case of metastatic adenocarcinoma of the pancreas with deafness being the patient's only reason for seeking medical attention. The patient had bilateral vestibulocochlear nerve palsies with associated lower motor neurone facial nerve palsies and a bulbar palsy. Magnetic resonance imaging of his brain was unremarkable. It was only on post-mortem histology that tumour infiltrating the leptomeninges was demonstrated. Leptomeningeal metastases are rarely associated with adenocarcinoma of the pancreas. A review of the literature reveals only two other case reports of mestatic pancreatic carcinoma presenting with deafness but both had demonstrable temporal bone lesions on MRI as opposed to the meninges.

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Year:  2012        PMID: 22743150     DOI: 10.1093/ageing/afs085

Source DB:  PubMed          Journal:  Age Ageing        ISSN: 0002-0729            Impact factor:   10.668


  7 in total

Review 1.  Gamma Knife treatment of recurrent CNS metastases of pancreatic origin: a case report and review of the literature.

Authors:  Subha Perni; Tony J Wang; Jerry Lesser; Christopher Mandigo; Steven R Isaacson; David P Horowitz
Journal:  CNS Oncol       Date:  2017-04

2.  Pancreatic cancer with leptomeningeal carcinomatosis: case report and literature review.

Authors:  Yuki Ikeda; Makoto Yoshida; Kazuma Ishikawa; Tomohiro Kubo; Kazuyuki Murase; Kohichi Takada; Koji Miyanishi; Junji Kato
Journal:  Int Cancer Conf J       Date:  2020-03-14

Review 3.  Malignant meningitis secondary to oesophageal adenocarcinoma presenting with sensorineural hearing loss: a series of three cases and discussion of the literature.

Authors:  Mark Adams; Carolynne Doherty; Anna O'Kane; Samuel Hall; Raeburn B Forbes; Brian Herron; Edward J McNaboe
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-12-08       Impact factor: 2.503

Review 4.  Leptomeningeal disease in pancreas ductal adenocarcinoma: A manifestation of longevity.

Authors:  Catherine A O'Connor; Jennifer S Park; Thomas Kaley; Brie Kezlarian; Marcia Edelweiss; T Jonathan Yang; Wungki Park; Diane Reidy; Anna M Varghese; Kenneth H Yu; Eileen M O'Reilly
Journal:  Pancreatology       Date:  2021-02-06       Impact factor: 3.996

5.  Leptomeningeal Carcinomatosis in a Patient with Pancreatic Cancer: A Rare Phenomenon?

Authors:  Taichi Sayanagi; Yumiko Ohishi; Makoto Katayama; Ryota Tamura
Journal:  Medicines (Basel)       Date:  2022-07-12

6.  Leptomeningeal Carcinomatosis in a Patient with Pancreatic Cancer Responding to Nab-Paclitaxel plus Gemcitabine.

Authors:  Garry Ceccon; Michael Wollring; Anna Brunn; Martina Deckert; Dirk Waldschmidt; Gereon R Fink; Norbert Galldiks
Journal:  Case Rep Oncol       Date:  2020-01-21

7.  Treatment Outcome of Nab-paclitaxel Plus Gemcitabine for Leptomeningeal Carcinomatosis from Pancreatic Ductal Adenocarcinoma: An Autopsy Case Report.

Authors:  Kunio Iwatsuka; Daiichiro Kikuta; Hitoshi Shibuya; Masahiro Ogawa; Takuji Gotoda; Mitsuhiko Moriyama; Hiroshi Nakagawara; Akihiro Hemmi; Kenji Yamao
Journal:  Intern Med       Date:  2021-06-19       Impact factor: 1.271

  7 in total

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