BACKGROUND: Use of mouthwash and an increased risk of oral cancer has been a source of controversy for decades. A meta-analysis of epidemiological studies of mouthwash and oral cancer and, specifically, mouthwash containing >25% alcohol, was undertaken. METHODS: Summary estimates were obtained with maximum likelihood estimates from random effects models. Sensitivity analyses were conducted to evaluate the influence of various inclusion. RESULTS: Eighteen studies were included in the meta-analysis. There was no statistically significant associations found between regular use of mouthwash and risk of oral cancer (RR=1.13; 95% CI (0.95-1.35)). There was no significant trend in risk of oral cancer associated with increased daily usage of mouthwash (p=0.11). There was no association between reported use of mouthwash specifically containing alcohol and risk of oral cancer (RR=1.16; 95% CI (0.44, 3.08)). CONCLUSIONS: This quantitative analysis of mouthwash use and oral malignancy revealed no statistically significant associations between mouthwash use and risk of oral cancer, nor any significant trend in risk with increasing daily use; and no association between use of mouthwash containing alcohol and oral cancer risk.
BACKGROUND: Use of mouthwash and an increased risk of oral cancer has been a source of controversy for decades. A meta-analysis of epidemiological studies of mouthwash and oral cancer and, specifically, mouthwash containing >25% alcohol, was undertaken. METHODS: Summary estimates were obtained with maximum likelihood estimates from random effects models. Sensitivity analyses were conducted to evaluate the influence of various inclusion. RESULTS: Eighteen studies were included in the meta-analysis. There was no statistically significant associations found between regular use of mouthwash and risk of oral cancer (RR=1.13; 95% CI (0.95-1.35)). There was no significant trend in risk of oral cancer associated with increased daily usage of mouthwash (p=0.11). There was no association between reported use of mouthwash specifically containing alcohol and risk of oral cancer (RR=1.16; 95% CI (0.44, 3.08)). CONCLUSIONS: This quantitative analysis of mouthwash use and oral malignancy revealed no statistically significant associations between mouthwash use and risk of oral cancer, nor any significant trend in risk with increasing daily use; and no association between use of mouthwash containing alcohol and oral cancer risk.
Authors: Paolo Boffetta; Richard B Hayes; Samantha Sartori; Yuan-Chin A Lee; Joshua Muscat; Andrew Olshan; Deborah M Winn; Xavier Castellsagué; Zuo-Feng Zhang; Hal Morgenstern; Chu Chen; Stephen M Schwartz; Thomas L Vaughan; Victor Wunsch-Filho; Mark Purdue; Sergio Koifman; Maria P Curado; Marta Vilensky; Maura Gillison; Leticia Fernandez; Ana Menezes; Alexander W Daudt; Stimson Schantz; Guopei Yu; Gypsyamber D'Souza; Robert I Haddad; Carlo La Vecchia; Mia Hashibe Journal: Eur J Cancer Prev Date: 2016-07 Impact factor: 2.497
Authors: José Manuel Calderón-Montaño; Julio José Jiménez-Alonso; Emilio Guillén-Mancina; Estefanía Burgos-Morón; Miguel López-Lázaro Journal: Clin Oral Investig Date: 2018-08-28 Impact factor: 3.573
Authors: Maira Castañeda-Avila; Cynthia M Pérez; José Vivaldi; Elba C Díaz-Toro; Hilmaris Centeno; Ana Patricia Ortiz Journal: J Health Dispar Res Pract Date: 2020