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Literature DB >> 22740396

Restricted varicella-zoster virus transcription in human trigeminal ganglia obtained soon after death.

Werner J D Ouwendijk¹, Alexander Choe, Maria A Nagel, Don Gilden, Albert D M E Osterhaus, Randall J Cohrs, Georges M G M Verjans.

Abstract

We analyzed the varicella-zoster virus (VZV) transcriptome in 43 latently infected human trigeminal ganglia (TG) with postmortem intervals (PMIs) ranging from 3.7 to 24 h. Multiplex reverse transcriptase PCR (RT-PCR) revealed no VZV transcripts with a PMI of <9 h. Real-time PCR indicated a significant increase (P = 0.02) in VZV ORF63 transcript levels but not the virus DNA burden with longer PMI. Overall, both the breadth of the VZV transcriptome and the VZV ORF63 transcript levels in human cadaver TG increased with longer PMI.

Entities: Gene Species

Mesh：

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Year: 2012 PMID： 22740396 PMCID： PMC3446590 DOI： 10.1128/JVI.01331-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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