BACKGROUND AND AIM: Pre-term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL12 (SDF-1) and CXCL10 (IP-10) in cord blood of term and pre-term delivered fetuses and their corresponding mothers. MATERIAL AND METHODS: Cord and peripheral blood samples were collected from 50 pre-term and 50 term infants and their mothers. Serum levels of CXCL12 and CXCL10 were measured by ELISA. RESULTS: The findings of this study indicated that the circulating levels of CXCL10 were elevated in mothers bearing pre-term infants, while CXCL12 was only increased in pre-term infants. CONCLUSION: The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
BACKGROUND AND AIM: Pre-term delivery is a mostly unknown frequent disorder worldwide. This project aimed to investigate the circulating levels of CXCL12 (SDF-1) and CXCL10 (IP-10) in cord blood of term and pre-term delivered fetuses and their corresponding mothers. MATERIAL AND METHODS: Cord and peripheral blood samples were collected from 50 pre-term and 50 term infants and their mothers. Serum levels of CXCL12 and CXCL10 were measured by ELISA. RESULTS: The findings of this study indicated that the circulating levels of CXCL10 were elevated in mothers bearing pre-term infants, while CXCL12 was only increased in pre-term infants. CONCLUSION: The results suggested that the pathophysiological status of both mother and infant are involved in prematurity. Moreover, these findings suggest an inflammatory response in pre-term labor, which probably is controlled by inducible chemokines such as CXCL10.
Authors: Josine E G Vaes; Myrna J V Brandt; Nikki Wanders; Manon J N L Benders; Caroline G M de Theije; Pierre Gressens; Cora H Nijboer Journal: Glia Date: 2020-11-30 Impact factor: 7.452
Authors: Rafał Rzepka; Barbara Dołęgowska; Aleksandra Rajewska; Daria Sałata; Marta Budkowska; Sebastian Kwiatkowski; Andrzej Torbé Journal: Biomed Res Int Date: 2016-07-31 Impact factor: 3.411