| Literature DB >> 33746400 |
Gholamhossein Hassanshahi1,2, Seyed Ebrahim Alavi3, Hossein Khorramdelazad1, Zahra Ahmadi1, Ali Fattahi Bafghi4, Seyed Hossein Abdollahi1,5, Hasan Ebrahimi Shahmabadi5.
Abstract
The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites. © Indian Society for Parasitology 2020.Entities:
Keywords: CC ligand; Chemokines; Leishmaniasis; Parasitic infection
Year: 2020 PMID： 33746400 PMCID： PMC7921228 DOI： 10.1007/s12639-020-01290-w
Source DB: PubMed Journal: J Parasit Dis ISSN： 0971-7196