| Literature DB >> 22734467 |
Yan-ping Zhu1, Mei-cai Liu, Feng-cheng Jia, Jing-jing Yuan, Qing-he Gao, Mi Lian, An-xin Wu.
Abstract
A molecular I(2)-promoted sp(3) C-H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and Friedel-Crafts reaction) were assembled in a single reactor. A variety of 2,2-bisindolyl-1-aryl ethanones were synthesized from simple and readily available aryl methyl ketones and indoles. In the reaction, metal, base, and ligand were all avoidable.Entities:
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Year: 2012 PMID： 22734467 DOI： 10.1021/ol301366p
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005