Literature DB >> 22730215

The interplay of monolayer structure and serum protein interactions on the cellular uptake of gold nanoparticles.

Zheng-Jiang Zhu1, Tamara Posati, Daniel F Moyano, Rui Tang, Bo Yan, Richard W Vachet, Vincent M Rotello.   

Abstract

A critical factor for controlling serum albumin binding is surface hydrophobicity, which in turn decreases the cellular uptake of gold nanoparticles. Hydrophobic nanoparticles bind albumin more tightly, inhibiting particle uptake, with a direct correlation observed between uptake and surface hydrophobicity.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22730215      PMCID： PMC3440774          DOI： 10.1002/smll.201200794

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  30 in total

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