Literature DB >> 2272914

Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity.

J G Ondeyka1, R T Goegelman, J M Schaeffer, L Kelemen, L Zitano.   

Abstract

Paraherquamide and six novel analogs were isolated from the fermentation of Penicillium charlesii (ATCC 20841). All seven natural products displayed potent antinematodal activity against Caenorhabditis elegans. None of the novel analogs were more potent than paraherquamide.

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Year:  1990        PMID： 2272914     DOI： 10.7164/antibiotics.43.1375

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  25 in total

1.  Study on the biosynthesis of the notoamides: Pinacol-type rearrangement of the isoprenyl unit in deoxybrevianamide E and 6-hydroxydeoxybrevianamide E.

Authors:  Hikaru Kato; Yuichi Nakamura; Jennifer M Finefield; Hideharu Umaoka; Takashi Nakahara; Robert M Williams; Sachiko Tsukamoto
Journal:  Tetrahedron Lett       Date:  2011-12-21       Impact factor: 2.415

2.  Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600.

Authors:  Jennifer M Finefield; Thomas J Greshock; David H Sherman; Sachiko Tsukamoto; Robert M Williams
Journal:  Tetrahedron Lett       Date:  2011-04-20       Impact factor: 2.415

3.  Studies Towards Paraherquamides E & F and Related C-labeled Putative Biosynthetic Intermediates: Stereocontrolled Synthesis of the α-Alkyl-β-Methylproline Ring System.

Authors:  Konrad Sommer; Robert M Williams
Journal:  Tetrahedron       Date:  2008-07-21       Impact factor: 2.457

4.  Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum.

Authors:  James D Sunderhaus; David H Sherman; Robert M Williams
Journal:  Isr J Chem       Date:  2011-04       Impact factor: 3.333

5.  Isolation and insecticidal activity of mellamide from Aspergillus melleus.

Authors:  J G Ondeyka; A W Dombrowski; J P Polishook; T Felcetto; W L Shoop; Z Guan; S B Singh
Journal:  J Ind Microbiol Biotechnol       Date:  2003-04-08       Impact factor: 3.346

6.  Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids.

Authors:  Jennifer M Finefield; Robert M Williams
Journal:  J Org Chem       Date:  2010-05-07       Impact factor: 4.354

7.  Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides.

Authors:  Amy E Fraley; Hong T Tran; Samantha P Kelly; Sean A Newmister; Ashootosh Tripathi; Hikaru Kato; Sachiko Tsukamoto; Lei Du; Shengying Li; Robert M Williams; David H Sherman
Journal:  Chembiochem       Date:  2020-05-14       Impact factor: 3.164

8.  Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp.

Authors:  Sachiko Tsukamoto; Hikaru Kato; Thomas J Greshock; Hiroshi Hirota; Tomihisa Ohta; Robert M Williams
Journal:  J Am Chem Soc       Date:  2009-03-25       Impact factor: 15.419

9.  Calmodulin inhibitory activity of the malbrancheamides and various analogs.

Authors:  Kenneth A Miller; Mario Figueroa; Meriah W N Valente; Thomas J Greshock; Rachel Mata; Robert M Williams
Journal:  Bioorg Med Chem Lett       Date:  2008-10-17       Impact factor: 2.823

10.  Biomimetic total synthesis of malbrancheamide and malbrancheamide B.

Authors:  Kenneth A Miller; Timothy R Welch; Thomas J Greshock; Yousong Ding; David H Sherman; Robert M Williams
Journal:  J Org Chem       Date:  2008-03-18       Impact factor: 4.354
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