Literature DB >> 18986806

Calmodulin inhibitory activity of the malbrancheamides and various analogs.

Kenneth A Miller1, Mario Figueroa, Meriah W N Valente, Thomas J Greshock, Rachel Mata, Robert M Williams.   

Abstract

The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.

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Year:  2008        PMID： 18986806      PMCID： PMC2629606          DOI： 10.1016/j.bmcl.2008.10.057

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

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Review 8.  Calmodulin, and various ways to regulate its activity.

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2.  Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids.

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Review 3.  Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.

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Review 5.  Halogenation in Fungi: What Do We Know and What Remains to Be Discovered?

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Review 6.  Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi.

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  6 in total

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