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Literature DB >> 22728844

Cyclotron produced ⁴⁴gSc from natural calcium.

G W Severin¹, J W Engle, H F Valdovinos, T E Barnhart, R J Nickles.

Abstract

(44g)Sc was produced by 16MeV proton irradiation of unenriched calcium metal with radionuclidic purity greater than 95%. The thick target yield at saturation for (44g)Sc was 213 MBq/μA, dwarfing the yields of contaminants (43)Sc,(44 m)Sc, (47)Sc and (48)Sc for practical bombardment times of 1-2h. Scandium was isolated from the dissolved calcium target by filtration, and reconstituted in small volumes of dilute HCl. Reactions with the chelate 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) indicated a reactivity of 54 ± 14 Gbq/μmol at end-of-bombardment.

Entities: CellLine Chemical Species

Mesh：

Substances：
Calcium

Year: 2012 PMID： 22728844 PMCID： PMC3393840 DOI： 10.1016/j.apradiso.2012.04.030

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

3 in total

1. Radiolabeling of DOTATOC with the long-lived positron emitter 44Sc.

Authors: Marek Pruszyński; Agnieszka Majkowska-Pilip; Natalia S Loktionova; Elisabeth Eppard; Frank Roesch
Journal: Appl Radiat Isot Date: 2012-03-18 Impact factor: 1.513

2. Post-elution processing of (44)Ti/(44)Sc generator-derived (44)Sc for clinical application.

Authors: M Pruszyński; N S Loktionova; D V Filosofov; F Rösch
Journal: Appl Radiat Isot Date: 2010-04-24 Impact factor: 1.513

3. Production and separation of non-carrier-added 86Y from enriched 86Sr targets.

Authors: Miguel A Avila-Rodriguez; Jonathon A Nye; Robert J Nickles
Journal: Appl Radiat Isot Date: 2007-08-09 Impact factor: 1.513

3 in total

13 in total

1. Coordination chemistry of [Y(pypa)]^- and comparison immuno-PET imaging of [⁴⁴Sc]Sc- and [⁸⁶Y]Y-pypa-phenyl-TRC105.

Authors: Lily Li; María de Guadalupe Jaraquemada-Peláez; Eduardo Aluicio-Sarduy; Xiaozhu Wang; Todd E Barnhart; Weibo Cai; Valery Radchenko; Paul Schaffer; Jonathan W Engle; Chris Orvig
Journal: Dalton Trans Date: 2020-04-09 Impact factor: 4.390

2. Separation of cyclotron-produced ⁴⁴Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin.

Authors: H F Valdovinos; R Hernandez; T E Barnhart; S Graves; W Cai; R J Nickles
Journal: Appl Radiat Isot Date: 2014-10-08 Impact factor: 1.513

Review 3. Cutting edge rare earth radiometals: prospects for cancer theranostics.

Authors: Alexander W E Sadler; Leena Hogan; Benjamin Fraser; Louis M Rendina
Journal: EJNMMI Radiopharm Chem Date: 2022-08-26

4. [^nat/44Sc(pypa)]^-: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate.

Authors: Lily Li; María de Guadalupe Jaraquemada-Peláez; Eduardo Aluicio-Sarduy; Xiaozhu Wang; Dawei Jiang; Meelad Sakheie; Hsiou-Ting Kuo; Todd E Barnhart; Weibo Cai; Valery Radchenko; Paul Schaffer; Kuo-Shyan Lin; Jonathan W Engle; François Bénard; Chris Orvig
Journal: Inorg Chem Date: 2020-01-24 Impact factor: 5.165

5. Matching the decay half-life with the biological half-life: ImmunoPET imaging with (44)Sc-labeled cetuximab Fab fragment.

Authors: Rubel Chakravarty; Shreya Goel; Hector F Valdovinos; Reinier Hernandez; Hao Hong; Robert J Nickles; Weibo Cai
Journal: Bioconjug Chem Date: 2014-11-24 Impact factor: 4.774

6. ⁴⁷Sc production development by cyclotron irradiation of ⁴⁸Ca.

Authors: R Misiak; R Walczak; B Wąs; M Bartyzel; J W Mietelski; A Bilewicz
Journal: J Radioanal Nucl Chem Date: 2017-06-13 Impact factor: 1.371

7. Production and separation of ⁴³Sc for radiopharmaceutical purposes.

Authors: Katharina A Domnanich; Robert Eichler; Cristina Müller; Sara Jordi; Vera Yakusheva; Saverio Braccini; Martin Behe; Roger Schibli; Andreas Türler; Nicholas P van der Meulen
Journal: EJNMMI Radiopharm Chem Date: 2017-11-25

8. (44)Sc: an attractive isotope for peptide-based PET imaging.

Authors: Reinier Hernandez; Hector F Valdovinos; Yunan Yang; Rubel Chakravarty; Hao Hong; Todd E Barnhart; Weibo Cai
Journal: Mol Pharm Date: 2014-07-23 Impact factor: 4.939

9. Cyclotron production of (43)Sc for PET imaging.

Authors: Rafał Walczak; Seweryn Krajewski; Katarzyna Szkliniarz; Mateusz Sitarz; Kamel Abbas; Jarosław Choiński; Andrzej Jakubowski; Jerzy Jastrzębski; Agnieszka Majkowska; Federica Simonelli; Anna Stolarz; Agnieszka Trzcińska; Wiktor Zipper; Aleksander Bilewicz
Journal: EJNMMI Phys Date: 2015-12-04

10. Separation of ⁴⁴Sc from Natural Calcium Carbonate Targets for Synthesis of ⁴⁴Sc-DOTATATE.

Authors: Krzysztof Kilian; Łukasz Cheda; Mateusz Sitarz; Katarzyna Szkliniarz; Jarosław Choiński; Anna Stolarz
Journal: Molecules Date: 2018-07-20 Impact factor: 4.411