| Literature DB >> 22726349 |
Tae Joon Won1, Bongjoon Kim, Yunjung Lee, Joon Seok Bang, Eun Seul Oh, Jong-Sun Yoo, Kyeong Eun Hyung, Joowon Yoon, Sehee Hwang, Eon Sub Park, So-Young Park, Kwang Woo Hwang.
Abstract
Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.Entities:
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Year: 2012 PMID： 22726349 DOI： 10.1016/j.cellimm.2012.05.013
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868