Literature DB >> 2272053

Antibody targeted therapy in cancer: comparison of murine and clinical studies.

R H Begent1, R B Pedley.   

Abstract

Antibody targeted therapy can be effective in animal models of cancer. Treatment has been less successful in man, though some responses are reported. Understanding the distribution of antibody in man and animals shows how toxicity may be minimized and patients selected for therapy on the basis of efficient antibody localization in the tumour.

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Year:  1990        PMID： 2272053     DOI： 10.1016/0305-7372(90)90071-m

Source DB:  PubMed          Journal:  Cancer Treat Rev        ISSN： 0305-7372            Impact factor:   12.111


  7 in total

Review 1.  Monoclonal antibody administration. Current clinical pharmacokinetic status and future trends.

Authors:  R H Begent; R B Pedley; J Begent
Journal:  Clin Pharmacokinet       Date:  1992-08       Impact factor: 6.447

Review 2.  Radio-immunotherapy dosimetry with special emphasis on SPECT quantification and extracorporeal immuno-adsorption.

Authors:  S E Strand; M Ljungberg; J Tennvall; K Norrgren; M Garkavij
Journal:  Med Biol Eng Comput       Date:  1994-09       Impact factor: 2.602

3.  Preparation, characterisation and tumour targeting of cross-linked divalent and trivalent anti-tumour Fab' fragments.

Authors:  J L Casey; D J King; L C Chaplin; A M Haines; R B Pedley; A Mountain; G T Yarranton; R H Begent
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

4.  Comparative radioimmunotherapy using intact or F(ab')2 fragments of 131I anti-CEA antibody in a colonic xenograft model.

Authors:  R B Pedley; J A Boden; R Boden; R Dale; R H Begent
Journal:  Br J Cancer       Date:  1993-07       Impact factor: 7.640

5.  Radioimmunotherapy of metastatic colorectal tumours with iodine-131-labelled antibody to carcinoembryonic antigen: phase I/II study with comparative biodistribution of intact and F(ab')2 antibodies.

Authors:  D M Lane; K F Eagle; R H Begent; L D Hope-Stone; A J Green; J L Casey; P A Keep; A M Kelly; J A Ledermann; M G Glaser
Journal:  Br J Cancer       Date:  1994-09       Impact factor: 7.640

6.  Orthotopic xenografts of human melanoma and colonic and ovarian carcinoma in sheep to evaluate radioimmunotherapy.

Authors:  J H Turner; A H Rose; R J Glancy; W J Penhale
Journal:  Br J Cancer       Date:  1998-08       Impact factor: 7.640

7.  The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody.

Authors:  R B Pedley; J A Boden; R Boden; R H Begent; A Turner; A M Haines; D J King
Journal:  Br J Cancer       Date:  1994-12       Impact factor: 7.640
  7 in total

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