Literature DB >> 22712693

The importance of preclinical trial timing - a potential reason for the disconnect between mouse studies and human clinical trials in ALS.

Qiongman Kong, Sarah Carothers, Yueming Chang, Chien-Liang Glenn Lin.   

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Year:  2012        PMID： 22712693      PMCID： PMC3572546          DOI： 10.1111/j.1755-5949.2012.00358.x

Source DB:  PubMed          Journal:  CNS Neurosci Ther        ISSN： 1755-5930            Impact factor:   5.243


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  10 in total

Review 1.  ALS: a disease of motor neurons and their nonneuronal neighbors.

Authors:  Séverine Boillée; Christine Vande Velde; Don W Cleveland
Journal:  Neuron       Date:  2006-10-05       Impact factor: 17.173

2.  A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS riluzole-tocopherol Study Group.

Authors:  C Desnuelle; M Dib; C Garrel; A Favier
Journal:  Amyotroph Lateral Scler Other Motor Neuron Disord       Date:  2001-03

3.  Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice.

Authors:  Shan Zhu; Irina G Stavrovskaya; Martin Drozda; Betty Y S Kim; Victor Ona; Mingwei Li; Satinder Sarang; Allen S Liu; Dean M Hartley; Du Chu Wu; Steven Gullans; Robert J Ferrante; Serge Przedborski; Bruce S Kristal; Robert M Friedlander
Journal:  Nature       Date:  2002-05-02       Impact factor: 49.962

4.  Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice.

Authors:  A Florence Keller; Mathieu Gravel; Jasna Kriz
Journal:  Exp Neurol       Date:  2010-12-17       Impact factor: 5.330

5.  Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

Authors:  Jeffrey D Rothstein; Sarjubhai Patel; Melissa R Regan; Christine Haenggeli; Yanhua H Huang; Dwight E Bergles; Lin Jin; Margaret Dykes Hoberg; Svetlana Vidensky; Dorothy S Chung; Shuy Vang Toan; Lucie I Bruijn; Zao-Zhong Su; Pankaj Gupta; Paul B Fisher
Journal:  Nature       Date:  2005-01-06       Impact factor: 49.962

6.  High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study.

Authors:  M Graf; D Ecker; R Horowski; B Kramer; P Riederer; M Gerlach; C Hager; A C Ludolph; G Becker; J Osterhage; W H Jost; B Schrank; C Stein; P Kostopulos; S Lubik; K Wekwerth; R Dengler; M Troeger; A Wuerz; A Hoge; C Schrader; N Schimke; K Krampfl; S Petri; S Zierz; K Eger; S Neudecker; K Traufeller; M Sievert; B Neundörfer; M Hecht
Journal:  J Neural Transm (Vienna)       Date:  2004-10-27       Impact factor: 3.575

7.  Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

Authors:  Paul H Gordon; Dan H Moore; Robert G Miller; Julaine M Florence; Joseph L Verheijde; Carolyn Doorish; Joan F Hilton; G Mark Spitalny; Robert B MacArthur; Hiroshi Mitsumoto; Hans E Neville; Kevin Boylan; Tahseen Mozaffar; Jerry M Belsh; John Ravits; Richard S Bedlack; Michael C Graves; Leo F McCluskey; Richard J Barohn; Rup Tandan
Journal:  Lancet Neurol       Date:  2007-11-05       Impact factor: 44.182

8.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

Authors:  M E Gurney; H Pu; A Y Chiu; M C Dal Canto; C Y Polchow; D D Alexander; J Caliendo; A Hentati; Y W Kwon; H X Deng
Journal:  Science       Date:  1994-06-17       Impact factor: 47.728

9.  Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

Authors:  Albert C Ludolph; Caterina Bendotti; Eran Blaugrund; Bastian Hengerer; Jean-Philippe Löffler; Joanne Martin; Vincent Meininger; Thomas Meyer; Saliha Moussaoui; Wim Robberecht; Sean Scott; Vincenzo Silani; Leonard H Van Den Berg
Journal:  Amyotroph Lateral Scler       Date:  2007-08

10.  Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.

Authors:  Yueming Chang; Qiongman Kong; Xiu Shan; Guilian Tian; Hristelina Ilieva; Don W Cleveland; Jeffrey D Rothstein; David R Borchelt; Philip C Wong; Chien-Liang Glenn Lin
Journal:  PLoS One       Date:  2008-08-06       Impact factor: 3.240
  10 in total
  10 in total

Review 1.  FTD and ALS--translating mouse studies into clinical trials.

Authors:  Lars M Ittner; Glenda M Halliday; Jillian J Kril; Jürgen Götz; John R Hodges; Matthew C Kiernan
Journal:  Nat Rev Neurol       Date:  2015-05-05       Impact factor: 42.937

2.  Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.

Authors:  Qiongman Kong; Ling-Chu Chang; Kou Takahashi; Qibing Liu; Delanie A Schulte; Liching Lai; Brian Ibabao; Yuchen Lin; Nathan Stouffer; Chitra Das Mukhopadhyay; Xuechao Xing; Kathleen I Seyb; Gregory D Cuny; Marcie A Glicksman; Chien-Liang Glenn Lin
Journal:  J Clin Invest       Date:  2014-02-24       Impact factor: 14.808

Review 3.  Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.

Authors:  Wenzhi Tan; Piera Pasinelli; Davide Trotti
Journal:  Biochim Biophys Acta       Date:  2014-02-22

Review 4.  Improving the predictive value of interventional animal models data.

Authors:  Caroline J Zeiss
Journal:  Drug Discov Today       Date:  2014-11-04       Impact factor: 7.851

Review 5.  Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation.

Authors:  Osama A Abulseoud; Fawaz Alasmari; Abdelaziz M Hussein; Youssef Sari
Journal:  Front Neurosci       Date:  2022-07-05       Impact factor: 5.152

Review 6.  ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis.

Authors:  Michael Jablonski; David S Miller; Piera Pasinelli; Davide Trotti
Journal:  Brain Res       Date:  2014-08-28       Impact factor: 3.252

Review 7.  Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis.

Authors:  Michael D Scofield; Peter W Kalivas
Journal:  Neuroscientist       Date:  2014-02-03       Impact factor: 7.519

8.  A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy.

Authors:  Leila Bond; Kamren Bernhardt; Priyank Madria; Katherine Sorrentino; Hailee Scelsi; Cassie S Mitchell
Journal:  Front Neurosci       Date:  2018-01-24       Impact factor: 4.677

9.  Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease.

Authors:  Caroline J Zeiss; Heather G Allore; Amanda P Beck
Journal:  PLoS One       Date:  2017-02-09       Impact factor: 3.240

10.  A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system.

Authors:  Jhan-Jie Peng; Shih-Han Lin; Yu-Tzu Liu; Hsin-Chieh Lin; Tsai-Ning Li; Chi-Kuang Yao
Journal:  Elife       Date:  2019-07-18       Impact factor: 8.140
  10 in total

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