| Literature DB >> 22710861 |
Nicolas Gouault1, Myriam Le Roch, Gisele de Campos Pinto, Michèle David.
Abstract
A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields.Entities:
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Year: 2012 PMID： 22710861 DOI： 10.1039/c2ob25685a
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876