Literature DB >> 22710702

Severe obesity: evidence for a deranged metabolic program in skeletal muscle?

Joseph A Houmard1, Walter J Pories, G Lynis Dohm.   

Abstract

Severe obesity is increasing at a disproportionate rate compared with milder grade obesity. Our research group has obtained evidence indicative of an "obesity metabolic program" in skeletal muscles of severely obese individuals, which may be determined genetically or epigenetically. We believe that this represents a paradigm shift in thinking about metabolic regulation in obesity.

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Year:  2012        PMID： 22710702      PMCID： PMC3458185          DOI： 10.1097/JES.0b013e31825d53fc

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  34 in total

1.  Effect of weight loss on muscle lipid content in morbidly obese subjects.

Authors:  Robert E Gray; Charles J Tanner; Walter J Pories; Kenneth G MacDonald; Joseph A Houmard
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-12-17       Impact factor: 4.310

2.  Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.

Authors:  Joseph A Houmard; Charles J Tanner; Chunli Yu; Paul G Cunningham; Walter J Pories; Kenneth G MacDonald; Gerald I Shulman
Journal:  Diabetes       Date:  2002-10       Impact factor: 9.461

3.  Skeletal muscle lipid metabolism with obesity.

Authors:  Matthew W Hulver; Jason R Berggren; Ronald N Cortright; Ronald W Dudek; R Peter Thompson; Walter J Pories; Kenneth G MacDonald; Gary W Cline; Gerald I Shulman; G Lynis Dohm; Joseph A Houmard
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-12-27       Impact factor: 4.310

4.  Muscle fiber type is associated with obesity and weight loss.

Authors:  Charles J Tanner; Hisham A Barakat; G Lynis Dohm; Walter J Pories; Kenneth G MacDonald; Paul R G Cunningham; Melvin S Swanson; Joseph A Houmard
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-06       Impact factor: 4.310

5.  Lipid oxidation is reduced in obese human skeletal muscle.

Authors:  J Y Kim; R C Hickner; R L Cortright; G L Dohm; J A Houmard
Journal:  Am J Physiol Endocrinol Metab       Date:  2000-11       Impact factor: 4.310

6.  Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.

Authors:  S I Itani; Q Zhou; W J Pories; K G MacDonald; G L Dohm
Journal:  Diabetes       Date:  2000-08       Impact factor: 9.461

7.  Substrate utilization during exercise in formerly morbidly obese women.

Authors:  N R Guesbeck; M S Hickey; K G MacDonald; W J Pories; I Harper; E Ravussin; G L Dohm; J A Houmard
Journal:  J Appl Physiol (1985)       Date:  2001-03

8.  Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance.

Authors:  Joseph T Brozinick; Brian R Roberts; G Lynis Dohm
Journal:  Diabetes       Date:  2003-04       Impact factor: 9.461

9.  Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia.

Authors:  C Pender; I D Goldfine; C J Tanner; W J Pories; K G MacDonald; P J Havel; J A Houmard; J F Youngren
Journal:  Int J Obes Relat Metab Disord       Date:  2004-03

10.  Protein kinase C modulates insulin action in human skeletal muscle.

Authors:  R N Cortright; J L Azevedo; Q Zhou; M Sinha; W J Pories; S I Itani; G L Dohm
Journal:  Am J Physiol Endocrinol Metab       Date:  2000-03       Impact factor: 4.310
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  13 in total

1.  Remembering those 'lazy' days--imprinting memory in our satellite cells.

Authors:  Ana P Valencia; Espen E Spangenburg
Journal:  J Physiol       Date:  2013-09-15       Impact factor: 5.182

2.  Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults.

Authors:  Seung J Choi; D Clark Files; Tan Zhang; Zhong-Min Wang; Maria L Messi; Heather Gregory; John Stone; Mary F Lyles; Sanjay Dhar; Anthony P Marsh; Barbara J Nicklas; Osvaldo Delbono
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-09-23       Impact factor: 6.053

3.  Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants.

Authors:  Terence E Ryan; Dean J Yamaguchi; Cameron A Schmidt; Tonya N Zeczycki; Saame Raza Shaikh; Patricia Brophy; Thomas D Green; Michael D Tarpey; Reema Karnekar; Emma J Goldberg; Genevieve C Sparagna; Maria J Torres; Brian H Annex; P Darrell Neufer; Espen E Spangenburg; Joseph M McClung
Journal:  JCI Insight       Date:  2018-11-02

Review 4.  Ockham's razor and the metabolic syndrome.

Authors:  Walter J Pories; Terry E Jones; Joseph A Houmard; Eric DeMaria; G Lynis Dohm
Journal:  Surg Obes Relat Dis       Date:  2021-04-09       Impact factor: 3.709

5.  Long maximal incremental tests accurately assess aerobic fitness in class II and III obese men.

Authors:  Stefano Lanzi; Franco Codecasa; Mauro Cornacchia; Sabrina Maestrini; Paolo Capodaglio; Amelia Brunani; Paolo Fanari; Alberto Salvadori; Davide Malatesta
Journal:  PLoS One       Date:  2015-04-13       Impact factor: 3.240

6.  Skeletal muscle myotubes in severe obesity exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux.

Authors:  Lance M Bollinger; Jonathan J S Powell; Joseph A Houmard; Carol A Witczak; Jeffrey J Brault
Journal:  Obesity (Silver Spring)       Date:  2015-06       Impact factor: 5.002

7.  Fat oxidation, hormonal and plasma metabolite kinetics during a submaximal incremental test in lean and obese adults.

Authors:  Stefano Lanzi; Franco Codecasa; Mauro Cornacchia; Sabrina Maestrini; Alberto Salvadori; Amelia Brunani; Davide Malatesta
Journal:  PLoS One       Date:  2014-02-11       Impact factor: 3.240

8.  Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice.

Authors:  Honglin Yan; Hui Diao; Yi Xiao; Wenxia Li; Bing Yu; Jun He; Jie Yu; Ping Zheng; Xiangbing Mao; Yuheng Luo; Benhua Zeng; Hong Wei; Daiwen Chen
Journal:  Sci Rep       Date:  2016-08-22       Impact factor: 4.379

9.  Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial.

Authors:  Tracey L Woodlief; Elvis A Carnero; Robert A Standley; Giovanna Distefano; Steve J Anthony; Gabe S Dubis; John M Jakicic; Joseph A Houmard; Paul M Coen; Bret H Goodpaster
Journal:  Obesity (Silver Spring)       Date:  2015-11-05       Impact factor: 5.002

10.  Insulin signaling pathway in the masseter muscle of dexamethasone-treated rats.

Authors:  Igor Rabelo de França; Daniela Meneses-Santos; Gabriela Virginia Moreira; Fábio Bessa Lima; Carla Roberta de Oliveira Carvalho; Anderson Carlos Marçal
Journal:  Interv Med Appl Sci       Date:  2018-12
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