Literature DB >> 22710175

Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators.

Alexander Wittmann1, Beatrix Suess.   

Abstract

Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22710175     DOI： 10.1016/j.febslet.2012.02.038

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  46 in total

1.  Synthetic biosensors for precise gene control and real-time monitoring of metabolites.

Authors:  Jameson K Rogers; Christopher D Guzman; Noah D Taylor; Srivatsan Raman; Kelley Anderson; George M Church
Journal:  Nucleic Acids Res       Date:  2015-07-07       Impact factor: 16.971

Review 2.  Global analysis of riboswitches by small-angle X-ray scattering and calorimetry.

Authors:  Jinwei Zhang; Christopher P Jones; Adrian R Ferré-D'Amaré
Journal:  Biochim Biophys Acta       Date:  2014-04-24

3.  Design criteria for synthetic riboswitches acting on transcription.

Authors:  Manja Wachsmuth; Gesine Domin; Ronny Lorenz; Robert Serfling; Sven Findeiß; Peter F Stadler; Mario Mörl
Journal:  RNA Biol       Date:  2015       Impact factor: 4.652

4.  Functional mining of transporters using synthetic selections.

Authors:  Hans J Genee; Anne P Bali; Søren D Petersen; Solvej Siedler; Mads T Bonde; Luisa S Gronenberg; Mette Kristensen; Scott J Harrison; Morten O A Sommer
Journal:  Nat Chem Biol       Date:  2016-10-03       Impact factor: 15.040

Review 5.  Optimization of industrial microorganisms: recent advances in synthetic dynamic regulators.

Authors:  Byung Eun Min; Hyun Gyu Hwang; Hyun Gyu Lim; Gyoo Yeol Jung
Journal:  J Ind Microbiol Biotechnol       Date:  2016-11-10       Impact factor: 3.346

Review 6.  Recent advances and future trends of riboswitches: attractive regulatory tools.

Authors:  Jean Paul Sinumvayo; Chunhua Zhao; Philibert Tuyishime
Journal:  World J Microbiol Biotechnol       Date:  2018-11-09       Impact factor: 3.312

Review 7.  The evolving interface between synthetic biology and functional metagenomics.

Authors:  Eric van der Helm; Hans J Genee; Morten O A Sommer
Journal:  Nat Chem Biol       Date:  2018-07-16       Impact factor: 15.040

8.  dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome.

Authors:  Judith S Bauer; Sven Fillinger; Konrad Förstner; Alexander Herbig; Adam C Jones; Katrin Flinspach; Cynthia Sharma; Harald Gross; Kay Nieselt; Alexander K Apel
Journal:  RNA Biol       Date:  2017-07-31       Impact factor: 4.652

Review 9.  Structure and function of preQ1 riboswitches.

Authors:  Catherine D Eichhorn; Mijeong Kang; Juli Feigon
Journal:  Biochim Biophys Acta       Date:  2014-05-04

10.  A general design strategy for protein-responsive riboswitches in mammalian cells.

Authors:  Simon Ausländer; Pascal Stücheli; Charlotte Rehm; David Ausländer; Jörg S Hartig; Martin Fussenegger
Journal:  Nat Methods       Date:  2014-10-05       Impact factor: 28.547
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