CONTEXT: Cadmium (Cd) is a widespread environmental pollutant that is associated with increased risk of osteoporosis. It has been proposed that Cd's toxic effect on bone is exerted via impaired activation of vitamin D, secondary to the kidney effects. OBJECTIVE: The present study was designed to investigate the damaging impact of Cd in drinking water on bone from biochemical and histopathological point of view. MATERIALS AND METHODS: This study was conducted on 30, 3-months-old female Sprague Dawley rats exposed to cadmium chloride in a dose of 50 mg Cd/L in drinking water for 3 months. Serum was taken for determination of calcium, phosphorous levels, parathyroid hormone, 1,25 dihydroxy vitamin D(3), osteocalcin (OC) and bone specific alkaline phosphatase (BALP) activity. RESULTS: The result revealed that Cd administration induces significant increase in serum calcium (Ca), phosphorous (P) and parathyroid hormone (PTH) levels in concomitant with significant reduction in serum vitamin D(3), osteocalcin (OC) levels and bone specific alkaline phosphatase (BALP) activity. CONCLUSION: The present study provided clear evidence that long-term exposure to cadmium chloride produced marked abnormalities in bone biomarkers and increasing risk of fracture.
CONTEXT: Cadmium (Cd) is a widespread environmental pollutant that is associated with increased risk of osteoporosis. It has been proposed that Cd's toxic effect on bone is exerted via impaired activation of vitamin D, secondary to the kidney effects. OBJECTIVE: The present study was designed to investigate the damaging impact of Cd in drinking water on bone from biochemical and histopathological point of view. MATERIALS AND METHODS: This study was conducted on 30, 3-months-old female Sprague Dawley rats exposed to cadmium chloride in a dose of 50 mg Cd/L in drinking water for 3 months. Serum was taken for determination of calcium, phosphorous levels, parathyroid hormone, 1,25 dihydroxy vitamin D(3), osteocalcin (OC) and bone specific alkaline phosphatase (BALP) activity. RESULTS: The result revealed that Cd administration induces significant increase in serum calcium (Ca), phosphorous (P) and parathyroid hormone (PTH) levels in concomitant with significant reduction in serum vitamin D(3), osteocalcin (OC) levels and bone specific alkaline phosphatase (BALP) activity. CONCLUSION: The present study provided clear evidence that long-term exposure to cadmium chloride produced marked abnormalities in bone biomarkers and increasing risk of fracture.
Authors: Pedro Luiz Menin Ruiz; Bianca Andrade Handan; Carolina Foot Gomes de Moura; Livia Ribeiro Assis; Kelly Rossetti Fernandes; Ana Claudia Muniz Renno; Daniel Araki Ribeiro Journal: Environ Sci Pollut Res Int Date: 2018-03-26 Impact factor: 4.223
Authors: V M Bimonte; Z M Besharat; A Antonioni; V Cella; A Lenzi; E Ferretti; S Migliaccio Journal: J Endocrinol Invest Date: 2021-01-26 Impact factor: 4.256
Authors: Marko Freese; Larissa Yokota Rizzo; Jan-Dag Pohlmann; Lasse Marohn; Paul Eckhard Witten; Felix Gremse; Stephan Rütten; Nihan Güvener; Sabrina Michael; Klaus Wysujack; Twan Lammers; Fabian Kiessling; Henner Hollert; Reinhold Hanel; Markus Brinkmann Journal: Proc Natl Acad Sci U S A Date: 2019-05-13 Impact factor: 11.205
Authors: Iwona Markiewicz-Górka; Krystyna Pawlas; Aleksandra Jaremków; Lidia Januszewska; Paweł Pawłowski; Natalia Pawlas Journal: Int J Environ Res Public Health Date: 2019-11-14 Impact factor: 3.390
Authors: L Moberg; P M Nilsson; G Samsioe; G Sallsten; L Barregard; G Engström; C Borgfeldt Journal: Osteoporos Int Date: 2017-04-21 Impact factor: 4.507