OBJECTIVES: It is currently unclear whether the parallels between abdominal aortic aneurysms (AAAs) and chronic obstructive pulmonary disease (COPD) are explained by common risk factors alone, such as cigarette smoking, or by a predetermined cause. Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth. METHODS: We conducted a case-control study comparing patients with a small AAA (maximum infrarenal diameter 35-50 mm, n = 221) with controls diagnosed with peripheral artery disease (PAD, n = 87). The controls were matched to the cases for lifetime cigarette smoking. Pulmonary function was measured by spirometry, and all subjects completed a questionnaire on medical history and smoking habits (current, former and never smokers). RESULTS: Aneurysm patients were similar to controls with respect to gender (p = 0.71), lifetime cigarette smoking (39 vs. 34 pack years, p = 0.23) and history of cardiovascular disease (45% vs. 55%, p = 0.12). Aneurysm patients had more airway obstruction (forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) (0.69 ± 0.12 vs. 0.78 ± 0.11, p < 0.001)), which was most pronounced in never smokers (0.73 ± 0.07 vs. 0.86 ± 0.07, p < 0.001). COPD was more prevalent in aneurysm patients (44%; 98/221) than in controls (20%; 17/87) (adjusted odds ratio (OR) 3.0; 95% confidence interval (95%CI) 1.6-5.5, p < 0.001). In particular, a major proportion of AAA patients was newly diagnosed with COPD; only 40 of 98 patients (41%) with COPD (mild, moderate or severe/very severe) were known before with obstructive pulmonary defects and received treatment. CONCLUSIONS: This study confirms an association between AAA and COPD and shows that this association is independent from smoking. Findings also demonstrate that COPD is under-diagnosed in AAA patients.
RCT Entities:
OBJECTIVES: It is currently unclear whether the parallels between abdominal aortic aneurysms (AAAs) and chronic obstructive pulmonary disease (COPD) are explained by common risk factors alone, such as cigarette smoking, or by a predetermined cause. Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth. METHODS: We conducted a case-control study comparing patients with a small AAA (maximum infrarenal diameter 35-50 mm, n = 221) with controls diagnosed with peripheral artery disease (PAD, n = 87). The controls were matched to the cases for lifetime cigarette smoking. Pulmonary function was measured by spirometry, and all subjects completed a questionnaire on medical history and smoking habits (current, former and never smokers). RESULTS:Aneurysmpatients were similar to controls with respect to gender (p = 0.71), lifetime cigarette smoking (39 vs. 34 pack years, p = 0.23) and history of cardiovascular disease (45% vs. 55%, p = 0.12). Aneurysmpatients had more airway obstruction (forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) (0.69 ± 0.12 vs. 0.78 ± 0.11, p < 0.001)), which was most pronounced in never smokers (0.73 ± 0.07 vs. 0.86 ± 0.07, p < 0.001). COPD was more prevalent in aneurysmpatients (44%; 98/221) than in controls (20%; 17/87) (adjusted odds ratio (OR) 3.0; 95% confidence interval (95%CI) 1.6-5.5, p < 0.001). In particular, a major proportion of AAA patients was newly diagnosed with COPD; only 40 of 98 patients (41%) with COPD (mild, moderate or severe/very severe) were known before with obstructive pulmonary defects and received treatment. CONCLUSIONS: This study confirms an association between AAA and COPD and shows that this association is independent from smoking. Findings also demonstrate that COPD is under-diagnosed in AAA patients.
Authors: Miguel J Divo; Carlos Cabrera; Ciro Casanova; Jose M Marin; Victor M Pinto-Plata; Juan P de-Torres; Javier Zulueta; Jorge Zagaceta; Pablo Sanchez-Salcedo; Juan Berto; Claudia Cote; Bartolome R Celli Journal: Chronic Obstr Pulm Dis Date: 2014-09-25
Authors: Ingo H Flessenkaemper; Robert Loddenkemper; Stephanie Roll; Kathrin Enke-Melzer; Henrik Wurps; Torsten T Bauer Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-06-10
Authors: Diane T Smelser; Gerard Tromp; James R Elmore; Helena Kuivaniemi; David P Franklin; H Lester Kirchner; David J Carey Journal: BMC Cardiovasc Disord Date: 2014-12-04 Impact factor: 2.298
Authors: Natasja W M Ramnath; Koen M van de Luijtgaarden; Ingrid van der Pluijm; Menno van Nimwegen; Paula M van Heijningen; Sigrid M A Swagemakers; Bibi S van Thiel; Ruziedi Y Ridwan; Nicole van Vliet; Marcel Vermeij; Luuk J A C Hawinkels; Anne de Munck; Oleh Dzyubachyk; Erik Meijering; Peter van der Spek; Robbert Rottier; Hiromi Yanagisawa; Rudi W Hendriks; Roland Kanaar; Ellen V Rouwet; Alex Kleinjan; Jeroen Essers Journal: PLoS One Date: 2014-09-25 Impact factor: 3.240