| Literature DB >> 22699377 |
Alex J Brown1, Daniel W Coyne.
Abstract
Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.Entities:
Mesh:
Substances:
Year: 2012 PMID: 22699377 DOI: 10.1038/ki.2012.135
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612